西班牙裔/拉丁裔人群中的阻塞性睡眠呼吸暂停与神经认知功能
Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population.
作者信息
Ramos Alberto R, Tarraf Wassim, Rundek Tatjana, Redline Susan, Wohlgemuth William K, Loredo Jose S, Sacco Ralph L, Lee David J, Arens Raanan, Lazalde Patricia, Choca James P, Mosley Thomas, González Hector M
机构信息
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
出版信息
Neurology. 2015 Jan 27;84(4):391-8. doi: 10.1212/WNL.0000000000001181. Epub 2014 Dec 24.
OBJECTIVE
We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States.
METHODS
Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief-Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores.
RESULTS
The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0-142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT-sum (β = -0.022) and -recall (β = -0.010), WF (β = -0.023), and DSS (β = -0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = -0.027, p < 0.10), SVELT-sum (β = -0.37), SVELT-recall (β = -0.010), and DSS (β = -0.061) at p < 0.01.
CONCLUSION
OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.
目的
我们评估了美国社区居住的西班牙裔/拉丁裔个体中阻塞性睡眠呼吸暂停（OSA）与神经认知功能之间的关联。
方法
对西班牙裔社区健康研究/拉丁裔研究中年龄在45至74岁的中年及老年成年人进行横断面分析，这些个体在2008年至2011年的基线测量中有神经认知测试分数。使用单词流畅性（WF）测试、简短西班牙语英语言语学习测试（SEVLT）和数字符号替换（DSS）测试来测量神经认知分数。OSA由呼吸暂停低通气指数（AHI）定义。采用多变量线性回归模型来评估OSA与神经认知分数之间的关系。
结果
分析包括8059名参与者，平均年龄56岁，55%为女性，41%的人受教育程度低于高中。平均AHI为9.0（范围0 - 142；正常AHI <5/小时）。AHI与所有4项神经认知测试分数之间存在关联：简短SEVLT - 总和（β = -0.022）和 - 回忆（β = -0.010）、WF（β = -0.023）以及DSS（β = -0.050），p < 0.01，且这种关联在年龄因素作用下完全减弱。在完全调整的回归模型中，女性性别是AHI与WF（β = -0.027，p < 0.10）、SVELT - 总和（β = -0.37）、SVELT - 回忆（β = -0.010）以及DSS（β = -0.061）之间关系的调节因素，p < 0.01。
结论
在美国西班牙裔/拉丁裔女性的代表性样本中，OSA与较差的神经认知功能相关。
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