Souza Breno Bernardes, Monteze Nayara Mussi, de Oliveira Fernando Luiz Pereira, de Oliveira José Magalhães, de Freitas Nascimento Silvia, Marques do Nascimento Neto Raimundo, Sales Maria Lilian, Souza Gabriela Guerra Leal
School of Medicine, Federal University of Ouro Preto, Ouro Preto, Brazil.
School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Brazil.
Occup Environ Med. 2015 Mar;72(3):208-15. doi: 10.1136/oemed-2014-102429. Epub 2014 Dec 24.
To evaluate the association between lifetime exposure to shift work and blood pressure, fasting glucose (FG), anthropometric variables, body composition and heart rate variability (HRV).
Male shift workers (N=438) were evaluated using principal component (PC) analysis. The variables used were: weight, body mass index (BMI), waist circumference (WC), neck circumference (NC), hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body fat mass (BFKg), body fat percentage (BF%), visceral fat area (VFA), FG, systolic (SBP) and diastolic blood pressure (DBP), and HRV variables. ECG was performed, extracting heart rate (HR), root mean square of the successive differences (RMSSD), high frequency (HF), low frequency (LF) and the LF/HF ratio. Using linear regression models, the lifetime shift work exposure was associated with each PC.
Five PCs were obtained, which accounted for 79.6% of the total variation of the data. PC1 (weight, BMI, WC, NC, HC, WHR, WHtR, BFKg, BF% and VFA) was designated as body obesity; PC2 (HF, RMSSD and LF) as good cardiac regulation; PC3 (SBP and DBP) as blood pressure; PC4 (LF/HF ratio and HR) as bad cardiac regulation and PC5 (WHR and FG) as insulin resistance. After age adjustment, the regression analysis showed that lifetime shift work was negatively associated with PC2 and positively associated with PC3.
The association of lifetime shift work exposure with PC2 and PC3 suggests that shift work promotes unfavourable changes in autonomic cardiac control related to a decrease in parasympathetic modulation and an increase in blood pressure.
评估终生从事轮班工作与血压、空腹血糖（FG）、人体测量学变量、身体成分及心率变异性（HRV）之间的关联。
使用主成分（PC）分析对男性轮班工人（N = 438）进行评估。所使用的变量包括：体重、体重指数（BMI）、腰围（WC）、颈围（NC）、臀围（HC）、腰臀比（WHR）、腰高比（WHtR）、体脂肪量（BFKg）、体脂肪百分比（BF%）、内脏脂肪面积（VFA）、FG、收缩压（SBP）和舒张压（DBP）以及HRV变量。进行心电图检查，提取心率（HR）、逐次差值的均方根（RMSSD）、高频（HF）、低频（LF）及LF/HF比值。使用线性回归模型，将终生轮班工作暴露与每个主成分相关联。
获得了5个主成分，它们占数据总变异的79.6%。主成分1（体重、BMI、WC、NC、HC、WHR、WHtR、BFKg、BF%和VFA）被指定为身体肥胖；主成分2（HF、RMSSD和LF）为良好的心脏调节；主成分3（SBP和DBP）为血压；主成分4（LF/HF比值和HR）为不良的心脏调节，主成分5（WHR和FG）为胰岛素抵抗。年龄调整后，回归分析表明终生轮班工作与主成分2呈负相关，与主成分3呈正相关。
终生轮班工作暴露与主成分2和主成分3的关联表明，轮班工作会促进自主心脏控制方面的不利变化，这与副交感神经调节减少和血压升高有关。
