Acar Banu Torun, Akdemir Mehmet Orcun, Acar Suphi
Ophthalmology Clinic, Haydarpasa Numune Research and Education Hospital, Istanbul 34668, Turkey.
Department of Ophthalmology, School of Medicine, Bulent Ecevit University, Zonguldak 67600, Turkey.
Int J Ophthalmol. 2014 Dec 18;7(6):974-9. doi: 10.3980/j.issn.2222-3959.2014.06.11. eCollection 2014.
To evaluate the visual acuity and endothelial cell density according to the thickness in Descemet's stripping automated endothelial keratoplasty (DSAEK) one year after surgery.
DSAEK patients' data were reviewed. Thirty-seven eyes of 37 patients who underwent DSAEK for pseudophakic bullous keratopathy (PBK) were included in this study. Graft thickness was measured with optical coherence tomography (OCT) 12mo after DSAEK. Eyes were divided into 3 groups based on the graft thickness: thick (>200 µm), medium-thick (150-200 µm) and thin (<150 µm). Best corrected visual acuity (BCVA), endothelial cells density (ECD) and complications were assessed and comparisons were done between groups.
There was no significant difference in age, sex, preoperative BCVA, or follow-up period between DSAEK groups. At postoperative 12mo, mean BCVA was 0.28±0.10 in thick graft group, 0.52±0.08 in medium-thick graft group, and 0.72±0.06 in thin graft group. Thin grafts showed better postoperative BCVA as compared with the medium-thick and thick grafts (P=0.001). Thick graft group had 1637.44±88.19-mm(2), medium thick graft had 1764.50±34.28-mm(2) and thin graft group had 1845.30±65.62-mm(2) ECD at 12mo after the surgery. Thin graft group had better ECD at 12mo after surgery (P=0.001).
Thin grafts after DSAEK ensure better visual rehabilitation. Eyes with thin grafts had significantly lesser loss of ECD compared to eyes with medium-thick and thick grafts one year after surgery.
评估深板层角膜内皮移植术（DSAEK）术后一年时，根据植片厚度的视力及内皮细胞密度情况。
回顾DSAEK患者的数据。本研究纳入37例因人工晶状体眼大泡性角膜病变（PBK）接受DSAEK手术的患者的37只眼。在DSAEK术后12个月时，使用光学相干断层扫描（OCT）测量植片厚度。根据植片厚度将眼部分为3组：厚（>200 µm）、中厚（150 - 200 µm）和薄（<150 µm）。评估最佳矫正视力（BCVA）、内皮细胞密度（ECD）及并发症，并在组间进行比较。
DSAEK组之间在年龄、性别、术前BCVA或随访时间上无显著差异。术后12个月时，厚植片组的平均BCVA为0.28±0.10，中厚植片组为0.52±0.08，薄植片组为0.72±0.06。与中厚和厚植片相比，薄植片术后BCVA更好（P = 0.001）。术后12个月时，厚植片组的ECD为1637.44±88.19/mm²，中厚植片组为1764.50±34.28/mm²，薄植片组为1845.30±65.62/mm²。薄植片组术后12个月时ECD更好（P = 0.001）。
DSAEK术后薄植片可确保更好的视力恢复。与中厚和厚植片的眼相比，术后一年时薄植片的眼ECD损失显著更少。
