Kitazawa Koji, Kayukawa Kanae, Wakimasu Koichi, Inatomi Tsutomu, Hieda Osamu, Mori Kazuhiko, Sotozono Chie, Kinoshita Shigeru
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.
Baptist Eye Institute, Kyoto, Japan.
Jpn J Ophthalmol. 2018 Nov;62(6):615-620. doi: 10.1007/s10384-018-0621-6. Epub 2018 Sep 25.
To investigate the effectiveness of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of cystoid macular edema (CME) post Descemet's stripping automated endothelial keratoplasty (DSAEK).
Retrospective observational study METHODS: In this study of 334 patients who underwent DSAEK at the Baptist Eye Institute, Kyoto, Japan between July 2011 and December 2015, 18 patients with postoperative CME (determined by optical coherence tomography) treated with topical NSAIDs after the onset of CME were included.
At CME onset, 17 of the 18 patients were treated with bromfenac eye drops and 1 was treated with nepafenac eye drops. Post initiation of treatment with topical NSAIDs, CME in 17 (94.4%) of the 18 patients improved at 1 month and all cases completely recovered within 3 months. At 12-months post initiation of treatment, 61.1% (n = 11) of patients achieved a visual acuity (VA) of 20/40 or better, and there was no significant difference of VA between the patients with or without an episode of postoperative CME (P = 0.55).
The administration of topical NSAID eye drops was found to be effective in treating patients with CME post DSAEK.
探讨局部应用非甾体类抗炎药（NSAIDs）治疗Descemet膜剥脱自动内皮角膜移植术（DSAEK）后黄斑囊样水肿（CME）的有效性。
回顾性观察研究
本研究纳入了2011年7月至2015年12月在日本京都浸信会眼科研究所接受DSAEK手术的334例患者，其中18例术后发生CME（通过光学相干断层扫描确定）且在CME发生后接受局部NSAIDs治疗的患者。
CME发生时，18例患者中有17例使用溴芬酸滴眼液治疗，1例使用奈帕芬酸滴眼液治疗。开始局部应用NSAIDs治疗后，18例患者中有17例（94.4%）在1个月时CME有所改善，所有病例在3个月内完全恢复。治疗开始后12个月时，61.1%（n = 11）的患者视力（VA）达到20/40或更好，术后发生CME的患者与未发生CME的患者之间的VA无显著差异（P = 0.55）。
发现局部应用NSAIDs滴眼液对治疗DSAEK术后CME患者有效。
