Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Network of Excellence for Functional Biomaterials (NFB), National University of Ireland, Galway (NUI Galway), Galway, Ireland.
Adv Drug Deliv Rev. 2015 Apr;84:240-56. doi: 10.1016/j.addr.2014.11.023. Epub 2014 Dec 24.
The last decade has seen significant developments in cell therapies, based on permanently differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative conditions. In vitro studies assess the influence of biophysical, biochemical and biological signals on tenogenic phenotype maintenance and/or differentiation towards tenogenic lineage. However, the ideal culture environment has yet to be identified due to the lack of standardised experimental setup and readout system. Bone marrow mesenchymal stem cells and tenocytes/dermal fibroblasts appear to be the cell populations of choice for clinical translation in equine and human patients respectively based on circumstantial, rather than on hard evidence. Collaborative, inter- and multi-disciplinary efforts are expected to provide clinically relevant and commercially viable cell-based therapies for tendon repair and regeneration in the years to come.
过去十年，基于永久性分化、重编程或工程化的干细胞的细胞疗法在肌腱损伤和退行性疾病方面取得了重大进展。体外研究评估了生物物理、生化和生物学信号对肌腱表型维持和/或向肌腱谱系分化的影响。然而，由于缺乏标准化的实验设置和读数系统，尚未确定理想的培养环境。骨髓间充质干细胞和肌腱细胞/真皮成纤维细胞似乎分别是马和人类患者临床转化的首选细胞群体，这主要是基于间接证据，而不是确凿证据。预计协作、跨学科和多学科的努力将在未来几年为肌腱修复和再生提供临床相关和商业可行的基于细胞的治疗方法。
