ABCB1基因多态性与糖皮质激素诱导的股骨头缺血性坏死易感性：一项荟萃分析。
ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis.
作者信息
Li Zhigang, Zhao Dewei, Wang Benjie
机构信息
Department of Orthopaedics, Affiliated Zhongshan Hospital, Dalian University, Dalian, Liaoning, China (mainland).
出版信息
Med Sci Monit. 2014 Dec 29;20:2811-6. doi: 10.12659/MSM.891286.
BACKGROUND
The results of studies on association between ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head (GANFH) are controversial. This study aimed to assess the association of ABCB1 gene polymorphisms with the risk of GANFH by conducting a meta-analysis.
MATERIAL AND METHODS
The PubMed, Cochrane Library, and Embase databases were searched for papers that describe the association between ABCB1 polymorphisms and GANFH risk. Summary odds ratios and 95% confidence intervals (CI) were estimated based on a fixed-effects model or random-effects model, depending on the absence or presence of significant heterogeneity.
RESULTS
A total of 5 studies and 833 patients were included in the final analysis. Significant differences were found for rs1045642 polymorphism in the comparisons of CC vs. CT+TT (OR, 1.462; 95% CI, 1.066-2.007; P=0.019), and rs2032582 polymorphism in the comparisons of GG vs. G(TA)+(TA)(TA) (OR, 1.548; 95% CI,1.063-2.255; P=0.023).
CONCLUSIONS
The study demonstrated that the ABCB1 polymorphisms (rs1045642 and rs2032582) significantly reduced the risk of GANFH.
背景
关于ABCB1基因多态性与糖皮质激素性股骨头缺血性坏死（GANFH）之间关联的研究结果存在争议。本研究旨在通过荟萃分析评估ABCB1基因多态性与GANFH风险的关联。
材料与方法
检索PubMed、Cochrane图书馆和Embase数据库，查找描述ABCB1基因多态性与GANFH风险之间关联的论文。根据是否存在显著异质性，基于固定效应模型或随机效应模型估计汇总比值比和95%置信区间（CI）。
结果
最终分析纳入了5项研究和833例患者。在CC与CT+TT的比较中，rs1045642基因多态性存在显著差异（OR，1.462；95%CI，1.066 - 2.007；P = 0.019）；在GG与G(TA)+(TA)(TA)的比较中，rs2032582基因多态性存在显著差异（OR，1.548；95%CI，1.063 - 2.255；P = 0.023）。
结论
该研究表明，ABCB1基因多态性（rs1045642和rs2032582）显著降低了GANFH的风险。
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