Zhou Zifei, Hua Yingqi, Liu Junjian, Zuo Dongqing, Wang Hongsheng, Chen Quanchi, Zheng Longpo, Cai Zhengdong
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China.
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, 301 Middle Yanchang Road, Shanghai 200072, China.
Gene. 2015 Sep 10;569(1):34-40. doi: 10.1016/j.gene.2015.03.023. Epub 2015 Mar 16.
Glucocorticoid-induced osteonecrosis of the femoral head (GC-induced ONFH) is a rebarbative disease affecting people from all ages, especially young adults, and often leads to severe joint pain and limitations on physical activity. Numerous studies have reported that ABCB1 polymorphisms are associated with GC-induced ONFH, but the results are inconclusive, partially because the sample size of published studies is relatively small. Therefore, we performed a meta-analysis including seven case-control studies to estimate such association.
Published literature from Medline, Embase, and CNKI were searched for eligible publications. Pooled odds ratio (OR) together with their 95% confidence (CI) was calculated using a fixed effect model or random effect model. The meta-analysis was performed in accordance to PRISMA Statement Criteria.
The ABCB1 3435T allele reduces the GC-induced ONFH risk based on the evidence from the co-dominant model (CT vs. CC, OR=0.73, 95% CI: 0.53-1.00; TT vs. CC, OR=0.43, 95% CI: 0.26-0.69), dominant model (CT+TT vs. CC, OR=0.64, 95% CI: 0.48-0.87), allele contract model, (T vs. C, OR=0.68, 95% CI: 0.54-0.84), and recessive model (TT vs. CC+CT, OR=0.52, 95% CI: 0.34-0.81). Similarly, the ABCB1 2677T/A allele reduce the GC-induced ONFH risk based on the evidence from the co-dominant model (GT/A vs. GG, OR=0.66, 95% CI: 0.45-0.96; T/AT/A vs. GG, OR=0.52, 95% CI: 0.34-0.82), dominant model (GT/A+T/AT/A vs. GG, OR=0.61, 95% CI: 0.43-0.87), and allele contract model (T/A vs. G, OR=0.73, 95% CI: 0.58-0.90).
The meta-analysis revealed that 3435T allele and ABCB1 2677T/A allele may decrease the risks of GC-induced ONFH.
糖皮质激素诱导的股骨头坏死（GC 诱导的 ONFH）是一种折磨各年龄段人群的难治性疾病，尤其在年轻人中常见，常导致严重的关节疼痛和身体活动受限。众多研究报道 ABCB1 基因多态性与 GC 诱导的 ONFH 相关，但结果尚无定论，部分原因是已发表研究的样本量相对较小。因此，我们进行了一项包含七项病例对照研究的荟萃分析，以评估这种关联。
检索 Medline、Embase 和中国知网的已发表文献，寻找符合条件的出版物。使用固定效应模型或随机效应模型计算合并比值比（OR）及其 95%置信区间（CI）。荟萃分析按照 PRISMA 声明标准进行。
基于共显性模型（CT 与 CC 相比，OR = 0.73，95%CI：0.53 - 1.00；TT 与 CC 相比，OR = 0.43，95%CI：0.26 - 0.69）、显性模型（CT + TT 与 CC 相比，OR = 0.64，95%CI：0.48 - 0.87）、等位基因对比模型（T 与 C 相比，OR = 0.68，95%CI：0.54 - 0.84）和隐性模型（TT 与 CC + CT 相比，OR = 0.52，95%CI：0.34 - 0.81）的证据，ABCB1 3435T 等位基因降低了 GC 诱导的 ONFH 风险。同样，基于共显性模型（GT/A 与 GG 相比，OR =
