Johnstone Paul, Strong Mark
Blenheim House, Leeds, UK.
BMJ Clin Evid. 2014 Dec 22;2014:1707.
Scabies is a common public health problem. In many resource-poor settings, scabies is an endemic problem; whereas in industrialised countries, it is most common in institutionalised communities.
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of topical treatments for scabies? What are the effects of systemic treatments for scabies? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found five studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review, we present information relating to the effectiveness and safety of the following interventions: benzyl benzoate (topical), crotamiton (topical), ivermectin (oral), malathion (topical), permethrin (topical), and sulfur compounds (topical).
疥疮是一个常见的公共卫生问题。在许多资源匮乏地区，疥疮是一个地方性问题；而在工业化国家，它在机构化社区中最为常见。
我们进行了一项系统评价，旨在回答以下临床问题：疥疮局部治疗的效果如何？疥疮全身治疗的效果如何？我们检索了：截至2013年7月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆以及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品与保健品管理局（MHRA）等相关组织的危害警示。
我们发现五项符合纳入标准的研究。我们对干预措施的证据质量进行了GRADE评估。
在本系统评价中，我们呈现了以下干预措施有效性和安全性的相关信息：苯甲酸苄酯（局部用药）、克罗米通（局部用药）、伊维菌素（口服）、马拉硫磷（局部用药）、氯菊酯（局部用药）以及含硫化合物（局部用药）。
