Anbar Tag S, El-Ammawi Tarek S, Abdel-Rahman Amal T, Hanna Michel R
Department of Dermatology, Al-Minya University, Al-Minya, Egypt.
Int J Dermatol. 2015;54(5):587-93. doi: 10.1111/ijd.12631. Epub 2014 Dec 29.
Latanoprost (LT), a prostaglandin F 2alpha (PGF2a ) analogue used in the treatment of glaucoma, was found to induce skin pigmentation in guinea pigs in addition to its known periocular and iridal pigmentation side effects. This study aims to evaluate the efficacy of topical LT in the induction of skin repigmentation in patients with vitiligo and to compare its potency with narrow band ultraviolet (UV) B (NB-UVB). The result of their combination was also assessed. This study involved 22 patients with bilateral and symmetrical vitiligo lesions, stable for the last three months, divided into three groups: group I, to evaluate LT vs. placebo; group II, to evaluate LT vs. NB-UVB; and group III, to evaluate the effect of their combination. The response to treatment was evaluated by taking photographic records of the treated lesions with follow-up photography every two weeks. After three months, assessment of the degree and extent of repigmentation was performed. Follow-up assessment was done six months after termination of the trial for the persistence of pigmentation, recurrence, or development of any side effects. LT was found to be better than placebo and comparable with the NB-UVB in inducing skin repigmentation. This effect was enhanced by the addition of NB-UVB. LT could be a promising treatment for vitiligo, especially the periocular variant. Its effect on skin repigmentation could be enhanced by NB-UVB exposure.
拉坦前列素（LT）是一种用于治疗青光眼的前列腺素F2α（PGF2α）类似物，除了已知的眼周和虹膜色素沉着副作用外，还被发现可诱导豚鼠皮肤色素沉着。本研究旨在评估局部应用LT对白癜风患者皮肤色素再生的疗效，并将其效力与窄谱紫外线（UV）B（NB-UVB）进行比较。还评估了两者联合使用的效果。本研究纳入了22例双侧对称性白癜风患者，其病情在过去三个月保持稳定，分为三组：第一组，评估LT与安慰剂的效果；第二组，评估LT与NB-UVB的效果；第三组，评估两者联合使用的效果。通过每两周对治疗部位进行摄影记录并随访拍照来评估治疗反应。三个月后，对色素再生的程度和范围进行评估。在试验结束六个月后进行随访评估，观察色素沉着的持续情况、复发情况或是否出现任何副作用。结果发现，在诱导皮肤色素再生方面，LT优于安慰剂，且与NB-UVB效果相当。NB-UVB的加入可增强这种效果。LT可能是一种有前景的白癜风治疗方法，尤其是对眼周型白癜风。暴露于NB-UVB可增强其对皮肤色素再生的效果。
