Pfaltzgraff Elise R, Bader David M
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee.
Dev Dyn. 2015 Mar;244(3):410-6. doi: 10.1002/dvdy.24247.
Regional differences in vascular physiology and disease response exist throughout the vascular tree. While these differences in physiology and disease correspond to regional vascular environmental conditions, there is also compelling evidence that the embryonic origins of the smooth muscle inherent to the vessels may play a role. Here, we review what is known regarding the role of embryonic origin of vascular smooth muscle cells during vascular development. The focus of this review is to highlight the heterogeneity in the origins of vascular smooth muscle cells and the resulting regional physiologies of the vessels. Our goal is to stimulate future investigation into this area and provide a better understanding of vascular organogenesis and disease. .
整个血管系统中存在血管生理学和疾病反应的区域差异。虽然这些生理学和疾病方面的差异与局部血管环境条件相对应，但也有令人信服的证据表明，血管固有平滑肌的胚胎起源可能起了作用。在此，我们综述了关于血管平滑肌细胞胚胎起源在血管发育过程中作用的已知情况。本综述的重点是突出血管平滑肌细胞起源的异质性以及由此产生的血管区域生理学特征。我们的目标是激发对该领域的未来研究，并更好地理解血管器官发生和疾病。
