Rajasekar Mani
Centre for Molecular and Nanomedical Sciences, International Research Centre, Sathyabama Institute of Science and Technology (Deemed to be University), Chennai 600 119, India.
Heliyon. 2021 Jan 24;7(1):e06066. doi: 10.1016/j.heliyon.2021.e06066. eCollection 2021 Jan.
Hesperetin derivatives were synthesized through the esterification of acid chlorides with hesperetin under ambient reaction conditions with good yields. The product was confirmed using different spectral techniques. It was treated on zebrafish embryos to study the lethality, phenotypic deformities, and toxicity level of the compound. In that assessment, embryos showed lethality towards at the minimal concentration. It assesses slow heartbeat since the compound loaded, the curvature on the back, upcurved fish, Cardiac chamber bulging, and poor survival rate in 72 h. shows less toxicity more than other compounds. It shows only pericardial edema at higher concentration and induced pericardial edema and upcurved tail at a medium range of the concentration. But both compounds were shown a good survival ratio at the minimal concentration.
橙皮素衍生物是在环境反应条件下通过酰氯与橙皮素的酯化反应合成的，产率良好。使用不同的光谱技术对产物进行了确认。将其作用于斑马鱼胚胎以研究该化合物的致死率、表型畸形和毒性水平。在该评估中，胚胎在最低浓度下就表现出致死性。它评估了自化合物加载以来的心跳缓慢、背部弯曲、鱼体上弯、心腔膨出以及72小时内较差的存活率。[此处原文可能有误，推测是指某一化合物]比其他化合物显示出更低的毒性。它仅在较高浓度下显示心包水肿，[此处原文可能有误，推测是指某一化合物]在中等浓度范围内诱导心包水肿和尾巴上弯。但两种化合物在最低浓度下均显示出良好的存活率。
