华支睾吸虫慢性感染及相关肝胆疾病与铁负载的M2样巨噬细胞有关。
Chronic Opisthorchis viverrini infection and associated hepatobiliary disease is associated with iron loaded M2-like macrophages.
作者信息
Bility Moses T, Sripa Banchob
机构信息
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Korean J Parasitol. 2014 Dec;52(6):695-9. doi: 10.3347/kjp.2014.52.6.695. Epub 2014 Dec 23.
Abstract
Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.
摘要
华支睾吸虫慢性感染所致肝胆疾病与显著的白细胞浸润有关，包括活化的巨噬细胞；然而，浸润巨噬细胞的极化情况仍有待全面阐明。在本研究中，我们运用基因表达和组织化学分析，对人类和仓鼠华支睾吸虫慢性感染所致肝胆疾病中的巨噬细胞极化和表型进行了特征描述。华支睾吸虫慢性感染及相关肝胆疾病在人类和仓鼠中均与铁负荷的M2样巨噬细胞有关。本研究提供了提示性证据，表明铁负荷的M2样巨噬细胞在华支睾吸虫慢性感染中促进肝胆疾病的发生。
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