Sevuk Utkan, Altindag Rojhat, Bahadir Mehmet Veysi, Ay Nurettin, Demirtas Ertan, Ayaz Fırat
Department of Cardiovascular Surgery, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey.
Department of Cardiology, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey.
Indian J Hematol Blood Transfus. 2015 Mar;31(1):71-6. doi: 10.1007/s12288-014-0365-5. Epub 2014 Apr 2.
We aimed to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) are helpful to identify complete thrombus resolution (CTR) after acute deep venous thrombosis (DVT). Patients who had first-time episode of acute proximal DVT were included in this retrospective study. 100 patients with DVT were divided into two groups according to absence (group 1; n = 68) or presence (group 2; n = 32) of CTR on doppler ultrasonography at month 6. There were no significant difference in admission MPV and PDW levels between group 1 and group 2. MPV (p = 0.03) and PDW (p < 0.001) levels at month 6 were significantly higher in group 1 than in group 2. CTR showed a moderate negative correlation with PDW at month 6 (ρ = -0.47) and a weak negative correlation with MPV at month 6 (ρ = -0.26). Logistic regression analysis showed that PDW (OR, 2.2; p = 0.004) at month 6 was an independent risk factor for the presence of residual venous thrombosis in DVT patients. Receiver operating characteristics analysis revealed that a 8.4 % decrease in admission MPV at month 6 provided 62 % sensitivity and 62 % specificity (AUC: 0.64) and a 15.4 % decrease in admission PDW at month 6 provided 87 % sensitivity and 94 % specificity (AUC: 0.89) for prediction of CTR in DVT patients. Percent change in admission MPV and PDW levels at month 6 may be used to identify the patients with CTR after a first episode of acute proximal DVT.
我们旨在评估平均血小板体积（MPV）和血小板分布宽度（PDW）是否有助于识别急性深静脉血栓形成（DVT）后血栓的完全溶解（CTR）。首次发生急性近端DVT的患者纳入本回顾性研究。100例DVT患者根据6个月时多普勒超声检查有无CTR分为两组，无CTR组（第1组；n = 68）和有CTR组（第2组；n = 32）。第1组和第2组入院时MPV和PDW水平无显著差异。第1组6个月时的MPV（p = 0.03）和PDW（p < 0.001）水平显著高于第2组。6个月时CTR与PDW呈中度负相关（ρ = -0.47），与MPV呈弱负相关（ρ = -0.26）。Logistic回归分析显示，6个月时的PDW（OR，2.2；p = 0.004）是DVT患者残留静脉血栓形成的独立危险因素。受试者工作特征分析显示，6个月时入院MPV降低8.4%可提供62%的敏感性和62%的特异性（AUC：0.64），6个月时入院PDW降低15.4%可提供87%的敏感性和94%的特异性（AUC：0.89），用于预测DVT患者的CTR。6个月时入院MPV和PDW水平的变化百分比可用于识别首次发生急性近端DVT后有CTR的患者。
