Omabe Maxwell, Nwudele Chibueze, Omabe Kenneth Nwobini, Okorocha Albert Egwu
Molecular Cancer Biology Research Group, Molecular Pathology and Immunology Division, Department of Medical Laboratory Sciences, School of Biomedical Science, Faculty of Health Science, Ebonyi State University, Nigeria ; Cancer Research Unit, Saskatchewan Cancer Agency, Room A 231, Health Science Building, University of Saskatchewan, Saskatoon, SK, Canada S7N 5R5.
Molecular Cancer Biology Research Group, Molecular Pathology and Immunology Division, Department of Medical Laboratory Sciences, School of Biomedical Science, Faculty of Health Science, Ebonyi State University, Nigeria.
J Toxicol. 2014;2014:406242. doi: 10.1155/2014/406242. Epub 2014 Dec 8.
Moringa oleifera (MO) is used for a number of therapeutic purposes. This raises the question of safety and possible toxicity. The objective of the study was to ascertain the safety and possible metabolic toxicity in comparison with metformin, a known drug associated with acidosis. Animals confirmed with diabetes were grouped into 2 groups. The control group only received oral dose of PBS while the test group was treated with ethanolic extract of MO orally twice daily for 5-6 days. Data showed that the extract significantly lowered glucose level to normal values and did not cause any significant cytotoxicity compared to the control group (P = 0.0698); there was no gain in weight between the MO treated and the control groups (P > 0.8115). However, data showed that treatment with an ethanolic extract of MO caused a decrease in bicarbonate (P < 0.0001), and more than twofold increase in anion gap (P < 0.0001); metformin treatment also decreased bicarbonate (P < 0.0001) and resulted in a threefold increase in anion gap (P < 0.0001). Conclusively, these data show that while MO appears to have antidiabetic and noncytotoxic properties, it is associated with statistically significant anion gap acidosis in alloxan induced type 2 diabetic rats.
辣木（MO）被用于多种治疗目的。这就引发了安全性和潜在毒性的问题。本研究的目的是与二甲双胍（一种已知与酸中毒相关的药物）相比，确定其安全性和可能的代谢毒性。确诊患有糖尿病的动物被分为两组。对照组仅口服磷酸盐缓冲盐水（PBS），而试验组每天口服两次辣木乙醇提取物，持续5 - 6天。数据显示，与对照组相比，该提取物显著降低血糖水平至正常范围，且未引起任何显著的细胞毒性（P = 0.0698）；辣木治疗组与对照组之间体重没有增加（P > 0.8115）。然而，数据显示，辣木乙醇提取物治疗导致碳酸氢盐减少（P < 0.0001），阴离子间隙增加两倍多（P < 0.0001）；二甲双胍治疗也导致碳酸氢盐减少（P < 0.0001），阴离子间隙增加三倍（P < 0.0001）。总之，这些数据表明，虽然辣木似乎具有抗糖尿病和无细胞毒性的特性，但在四氧嘧啶诱导的2型糖尿病大鼠中，它与具有统计学意义的阴离子间隙酸中毒有关。
