Trousdale M D, Barlow W E, McGuigan L J
Doheny Eye Institute, Los Angeles, CA 90033.
Arch Ophthalmol. 1989 Nov;107(11):1664-6. doi: 10.1001/archopht.1989.01070020742039.
Topical diclofenac sodium is a non-steroidal anti-inflammatory drug that is being developed for use in the control of postoperative and medical inflammation. A comparison was made of 0.1% diclofenac with 1% prednisolone sodium phosphate, 0.03% flurbiprofen, and a vehicle placebo in rabbit eyes with acute herpetic keratitis in a double-masked study. Maximum corneal epithelial involvement was observed in each group on day 6 postinoculation, and in eyes subsequently treated with prednisolone, the corneal epithelial involvement appeared to be more severe and to resolve more slowly. Conjunctivitis and corneal clouding peaked on days 6 to 7 for all treatment groups and remained most severe in the placebo-treated eyes, followed closely by those treated with prednisolone. The duration of virus shedding was the same for placebo-, flurbiprofen-, and diclofenac-treated groups (50% or more were virus negative by day 10 or 11). Only prednisolone-treated eyes had an extended period of virus shedding, and the rabbit mortality rate in this group was slightly higher. It thus appears that topical diclofenac does not exacerbate acute herpes keratitis; diclofenac-treated eyes displayed less or at least no more severe disease than did the eyes treated with the other anti-inflammatory agents tested, and shedding of virus into tears was not prolonged.
局部用双氯芬酸钠是一种正在研发用于控制术后炎症和药物性炎症的非甾体抗炎药。在一项双盲研究中，对0.1%双氯芬酸与1%泼尼松龙磷酸钠、0.03%氟比洛芬以及赋形剂安慰剂在患有急性疱疹性角膜炎的兔眼中进行了比较。接种后第6天在每组中观察到最大程度的角膜上皮受累情况，在随后用泼尼松龙治疗的眼中，角膜上皮受累似乎更严重且消退更缓慢。所有治疗组的结膜炎和角膜混浊在第6至7天达到峰值，在安慰剂治疗的眼中仍然最严重，其次是泼尼松龙治疗的眼。安慰剂、氟比洛芬和双氯芬酸治疗组的病毒排出持续时间相同（到第10天或11天，50%或更多为病毒阴性）。只有泼尼松龙治疗的眼有延长的病毒排出期，且该组兔的死亡率略高。因此，似乎局部用双氯芬酸不会加重急性疱疹性角膜炎；与用其他测试的抗炎药治疗的眼相比，双氯芬酸治疗的眼表现出较轻或至少没有更严重的疾病，并且病毒向泪液中的排出没有延长。
