Kaye S B, Madan N, Dowd T C, Hart C A, McCarthy K, Patterson A
St Paul's Eye Hospital, Liverpool.
Br J Ophthalmol. 1990 Feb;74(2):114-6. doi: 10.1136/bjo.74.2.114.
The presence, frequency, and relationship of ocular and oral shedding of herpes simplex virus to previous herpes keratitis was investigated. This was to determine if a history of herpes keratitis predisposes to shedding of the herpes simplex virus into the tear film and/or mouth. Swabs were collected from the eyes and mouth of two groups of patients thrice weekly over a two- to four-month period. Group A comprised nine patients with a history of herpes labialis, group B 15 patients with a history of herpes keratitis. Herpes simplex virus type 1 was isolated from 1.33% of mouth specimens but was not identified in any of the ocular specimens. There was no significant difference between groups A and B in terms of ocular or oral shedding. Oral shedding appears to be independent of a previous herpes keratitis. The tear film is an unlikely source of virus in persons either with no history of herpes keratitis or between attacks in those patients with a history of previous herpes keratitis.
研究了单纯疱疹病毒在眼部和口腔的存在情况、出现频率以及与既往疱疹性角膜炎的关系。目的是确定疱疹性角膜炎病史是否会使单纯疱疹病毒更容易脱落至泪膜和/或口腔。在两至四个月的时间里，每周三次从两组患者的眼睛和口腔采集拭子。A组包括9名有唇疱疹病史的患者，B组包括15名有疱疹性角膜炎病史的患者。从1.33%的口腔标本中分离出1型单纯疱疹病毒，但在任何眼部标本中均未检测到。A组和B组在眼部或口腔病毒脱落方面无显著差异。口腔病毒脱落似乎与既往疱疹性角膜炎无关。对于无疱疹性角膜炎病史的人或有既往疱疹性角膜炎病史的患者在发作间期，泪膜不太可能是病毒的来源。
