Alkuraishy Hayder M, Al-Gareeb Ali I, Albuhadilly Ali K
Department of Pharmacology, Toxicology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
Department of Pharmacology and Medicine, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq.
Biomed Res Int. 2014;2014:324307. doi: 10.1155/2014/324307. Epub 2014 Dec 7.
Blood and plasma viscosity are the major factors affecting blood flow and normal circulation. Whole blood viscosity is mainly affected by plasma viscosity, red blood cell deformability/aggregation and hematocrit, and other physiological factors. Thirty patients (twenty males + ten females) with age range 50-65 years, normotensive with history of cerebrovascular disorders, were selected according to the American Heart Stroke Association. Blood viscosity and other rheological parameters were measured after two-day abstinence from any medications. Dual effects of vinpocetine and pyritinol exhibit significant effects on all hemorheological parameters (P < 0.05), especially on low shear whole blood viscosity (P < 0.01), but they produced insignificant effects on total serum protein and high shear whole blood viscosity (P > 0.05). Therefore, joint effects of vinpocetine and pyritinol improve blood and plasma viscosity in patients with cerebrovascular disorders.
血液和血浆粘度是影响血流和正常循环的主要因素。全血粘度主要受血浆粘度、红细胞变形性/聚集性和血细胞比容以及其他生理因素的影响。根据美国心脏中风协会的标准，选取了30名年龄在50 - 65岁之间、血压正常且有脑血管疾病史的患者（20名男性 + 10名女性）。在停药两天后测量血液粘度和其他流变学参数。长春西汀和吡硫醇的联合作用对所有血液流变学参数均有显著影响（P < 0.05），尤其对低切变率全血粘度有显著影响（P < 0.01），但对总血清蛋白和高切变率全血粘度影响不显著（P > 0.05）。因此，长春西汀和吡硫醇的联合作用可改善脑血管疾病患者的血液和血浆粘度。
