Satoh Masaaki, Kotani Kazuhiko, Gugliucci Alejandro, Horie Hisanaga, Caccavello Russell, Takeuchi Mamoru
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
Department of Clinical Laboratory Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan ; Glycation, Oxidation and Disease Laboratory, Touro University California, 1310 Club Dr, Vallejo, CA 94594, USA.
ScientificWorldJournal. 2014;2014:959075. doi: 10.1155/2014/959075. Epub 2014 Dec 8.
Critical illnesses are assessed according to the sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation (APACHE) II. Circulating ischemia-modified albumin (IMA) is a biomarker generated under ischemic and oxidative conditions and may reflect disease severity in preoperative patients. This study investigated the correlations of IMA with SOFA and APACHE II scores in inpatients admitted for colorectal surgery.
We examined 27 patients with advanced colorectal cancers (mean age 69 years, men/women=15/12). Correlations between SOFA and APACHE II scores in addition to preoperative serum IMA and C-reactive protein (CRP) levels were analyzed.
The mean IMA level was 0.5 AU, and the median CRP level was 0.6 mg/dL. Median scores for SOFA and APACHE II were 2 and 12 points, respectively. Significant positive correlations between IMA and SOFA (r=0.45, P<0.05) and IMA and APACHE II (r=0.45, P<0.05) were identified which remained significant in confounder-adjusted analyses. In contrast, weak correlations were observed between CRP and the SOFA and APACHE II scores.
The positive correlations between IMA and both SOFA and APACHE II scores suggest that serum IMA measurements reflect the severity of systemic failure in patients admitted for colorectal surgery in the preoperative phase.
根据序贯器官衰竭评估（SOFA）和急性生理与慢性健康状况评估（APACHE）II对危重病进行评估。循环缺血修饰白蛋白（IMA）是在缺血和氧化条件下产生的一种生物标志物，可能反映术前患者的疾病严重程度。本研究调查了IMA与接受结直肠手术住院患者的SOFA和APACHE II评分之间的相关性。
我们检查了27例晚期结直肠癌患者（平均年龄69岁，男/女 = 15/12）。分析了SOFA和APACHE II评分与术前血清IMA和C反应蛋白（CRP）水平之间的相关性。
平均IMA水平为0.5 AU，CRP中位数水平为0.6 mg/dL。SOFA和APACHE II的中位数评分分别为2分和12分。IMA与SOFA（r = 0.45，P < 0.05）以及IMA与APACHE II（r = 0.45，P < 0.05）之间存在显著正相关，在混杂因素调整分析中仍然显著。相比之下，观察到CRP与SOFA和APACHE II评分之间的相关性较弱。
IMA与SOFA和APACHE II评分之间的正相关表明，血清IMA测量反映了术前接受结直肠手术患者全身衰竭的严重程度。
