Reproductive Biology and Assisted Conception Laboratory (G.A.T., M.P.G., D.K.G.), School of Biosciences, The University of Melbourne, Melbourne, Victoria, Australia 3010; Fundación Instituto Valenciano de Infertilidad (F.D., F.V., C.S.), Department of Obstetrics and Gynecology, University of Valencia, 46010, Valencia, Spain; La Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana Health Research Institute (F.D., F.V., C.S.), 46010 Valencia, Spain; and Department of Obstetrics and Gynecology (C.S.), Stanford University, Stanford, California 90095.
Endocr Rev. 2015 Feb;36(1):92-130. doi: 10.1210/er.2014-1046. Epub 2014 Dec 30.
Extensive evidence suggests that soluble ligands and their receptors mediate human preimplantation embryo development and implantation. Progress in this complex area has been ongoing since the 1980s, with an ever-increasing list of candidates. This article specifically reviews evidence of soluble ligands and their receptors in the human preimplantation stage embryo and female reproductive tract. The focus will be on candidates produced by the human preimplantation embryo and those eliciting developmental responses in vitro, as well as endometrial factors related to implantation and receptivity. Pathways to clinical translation, including innovative diagnostics and other technologies, are also highlighted, drawing from this collective evidence toward facilitating joint improvements in embryo quality and endometrial receptivity. This strategy could not only benefit clinical outcomes in reproductive medicine but also provide broader insights into the peri-implantation period of human development to improve fetal and neonatal health.
大量证据表明，可溶性配体及其受体介导了人类着床前胚胎的发育和着床。自 20 世纪 80 年代以来，这个复杂领域一直在不断发展，候选物的数量也在不断增加。本文专门回顾了可溶性配体及其受体在人类着床前胚胎和女性生殖道中的证据。重点将放在由人类着床前胚胎产生的候选物以及在体外引起发育反应的候选物上，以及与着床和容受性相关的子宫内膜因子。还从这些综合证据中强调了通向临床转化的途径，包括创新的诊断和其他技术，旨在促进胚胎质量和子宫内膜容受性的共同改善。这种策略不仅可以有益于生殖医学的临床结果，还可以更广泛地了解人类发育的着床期，以改善胎儿和新生儿的健康。
