微小RNA-139-3p提示结肠癌预后不良。
MicroRNA-139-3p indicates a poor prognosis of colon cancer.
作者信息
Liu Xiaojing, Duan Bensong, Dong Yuanyuan, He Chengzhi, Zhou Hongmei, Sheng Haihui, Gao Hengjun, Zhang Xizhi
机构信息
Department of Oncology, Subei People's Hospital, Clinical Medical College of Yangzhou University Yangzhou, Jiangsu, China.
Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China.
出版信息
Int J Clin Exp Pathol. 2014 Oct 15;7(11):8046-52. eCollection 2014.
MicroRNAs (miRNAs) play an important role in the regulation of gene expression and are involved in almost biological procession. Recently, miR-139-5p has been reported to be downregulated in some types of cancer, and inhibits cancer cell invasion and metastasis. However, there are few reports on the role of miR-139-3p in cancer. In this study, we examined the expression level of miR-139-3p in 63 pairs of colon cancer and adjacent paracancerous tissues using quantitative reverse transcription PCR. The levels of miR-139-3p in colon cancer tissues were significantly lower than those in adjacent noncancerous tissues. There was an inverse correlation between the level of miR-139-3p and patient's age. Lower level of miR-139-3p was significantly associated with poor overall survival, especially in patients with TNM stages I and II. In conclusion, miR-139-3p has potential as a prognostic biomarker for colon cancer. Further prospective studies are required to validate this result.
微小RNA（miRNA）在基因表达调控中发挥着重要作用，几乎参与所有生物学过程。最近，有报道称miR-139-5p在某些类型的癌症中表达下调，并抑制癌细胞的侵袭和转移。然而，关于miR-139-3p在癌症中的作用报道较少。在本研究中，我们使用定量逆转录PCR检测了63对结肠癌组织和癌旁组织中miR-139-3p的表达水平。结肠癌组织中miR-139-3p的水平显著低于相邻的非癌组织。miR-139-3p水平与患者年龄呈负相关。miR-139-3p水平较低与总体生存率较差显著相关，尤其是在TNM I期和II期患者中。总之，miR-139-3p有潜力作为结肠癌的预后生物标志物。需要进一步的前瞻性研究来验证这一结果。
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