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本文引用的文献

1
PBK/TOPK expression in non-small-cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression.PBK/TOPK 在非小细胞肺癌中的表达：与 Ki67 和 p53 表达的相关性及其预后意义。
Histopathology. 2013 Nov;63(5):696-703. doi: 10.1111/his.12215. Epub 2013 Sep 11.
2
Expression of HAb18G/CD147 and its localization correlate with the progression and poor prognosis of non-small cell lung cancer.HAb18G/CD147 的表达及其定位与非小细胞肺癌的进展和不良预后相关。
Pathol Res Pract. 2013 Jun;209(6):345-52. doi: 10.1016/j.prp.2013.02.015. Epub 2013 Mar 25.
3
Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation.在配对的恶性外周神经鞘瘤/丛状神经纤维瘤样本中对 519 个激酶基因的表达谱进行分析具有鉴别能力，并发现有丝分裂调节剂 BUB1B、PBK 和 NEK2 随着肿瘤转化而过度表达。
Mod Pathol. 2013 Jul;26(7):930-43. doi: 10.1038/modpathol.2012.242. Epub 2013 Feb 1.
4
c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas.c-Myc 和 E2F1 驱动高级恶性淋巴瘤中 PBK/TOPK 的表达。
Leuk Res. 2013 Apr;37(4):447-54. doi: 10.1016/j.leukres.2012.11.010. Epub 2012 Dec 10.
5
Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pathological characteristics.EZH2 表达的定量分析及其与肺癌患者临床病理特征的相关性。
Clin Transl Oncol. 2013 Feb;15(2):132-8. doi: 10.1007/s12094-012-0897-9. Epub 2012 Jul 24.
6
Overexpression of T-LAK cell-originated protein kinase predicts poor prognosis in patients with stage I lung adenocarcinoma.T 细胞淋巴瘤激酶起源蛋白激酶的过表达预示着 I 期肺腺癌患者的预后不良。
Cancer Sci. 2012 Apr;103(4):731-8. doi: 10.1111/j.1349-7006.2011.02197.x. Epub 2012 Feb 3.
7
TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer.TOPK/PBK 通过调节 PI3K/PTEN/AKT 通路促进细胞迁移，与肺癌的不良预后相关。
Oncogene. 2012 May 10;31(19):2389-400. doi: 10.1038/onc.2011.419. Epub 2011 Sep 26.
8
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway.T-LAK 细胞起源的蛋白激酶 (TOPK) 对 MKP1 蛋白的磷酸化通过抑制 p38 蛋白信号通路防止太阳紫外线诱导的炎症。
J Biol Chem. 2011 Aug 26;286(34):29601-9. doi: 10.1074/jbc.M111.225813. Epub 2011 Jun 29.
9
T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.T-LAK 细胞来源的蛋白激酶 (TOPK) 在丝氨酸 32 位磷酸化 Prx1 可通过调节 Prx1 过氧化物酶活性防止 RPMI7951 黑素瘤细胞中 UVB 诱导的细胞凋亡。
J Biol Chem. 2010 Sep 17;285(38):29138-46. doi: 10.1074/jbc.M110.135905. Epub 2010 Jul 20.
10
Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.TOPK 分层分析 KRAS 和 BRAF 基因突变对散发性、遗传性和转移性结直肠癌患者的预后和预测价值。
Br J Cancer. 2010 Jan 5;102(1):151-61. doi: 10.1038/sj.bjc.6605452. Epub 2009 Nov 24.

PBK/TOPK在宫颈癌及宫颈上皮内瘤变中的表达。

Expression of PBK/TOPK in cervical cancer and cervical intraepithelial neoplasia.

作者信息

Luo Qiong, Lei Bin, Liu Shuguang, Chen Yaowen, Sheng Wenjie, Lin Peixin, Li Wenxia, Zhu Haili, Shen Hong

机构信息

Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Oncology, Leiyang People's Hospital Leiyang City, Hunan Province, China.

Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou City, Guangdong Province, China ; Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou City, Guangdong Province, China.

出版信息

Int J Clin Exp Pathol. 2014 Oct 15;7(11):8059-64. eCollection 2014.

PMID:25550851
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270522/
Abstract

UNLABELLED

objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia.

METHODS

PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical cancer by immunohistochemistry (IHC). Then, the correlation between PBK/TOPK expression and clinicopathological features was quantitatively analyzed by measuring the positive unit (PU).

RESULTS

PBK/TOPK expression was significantly greater in cervical cancer than that in high-grade intraepithelial neoplasia and CINI (P < 0.05). Meanwhile, PBK/TOPK expression in high-grade intraepithelial neoplasia was significantly higher compared with that in CINI (P < 0.05). In addition, PBK/TOPK expression in cervical cancer significantly correlated with histological type, differentiation, lymph node metastasis, vaginal and cervical invasion, TNM stage and tumor size (P < 0.05).

CONCLUSION

PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.

摘要

未标记

目的：评估PBK/TOPK（PDZ结合激酶/T-LAK细胞起源蛋白激酶）在宫颈癌和宫颈上皮内瘤变中的表达及其临床意义。

方法

采用免疫组织化学（IHC）检测28例低级别宫颈上皮内瘤变（CINI）、62例高级别上皮内瘤变和80例宫颈癌中PBK/TOPK的表达。然后，通过测量阳性单位（PU）对PBK/TOPK表达与临床病理特征之间的相关性进行定量分析。

结果

PBK/TOPK在宫颈癌中的表达明显高于高级别上皮内瘤变和CINI（P<0.05）。同时，高级别上皮内瘤变中PBK/TOPK的表达明显高于CINI（P<0.05）。此外，宫颈癌中PBK/TOPK的表达与组织学类型、分化程度、淋巴结转移、阴道和宫颈浸润、TNM分期及肿瘤大小显著相关（P<0.05）。

结论

PBK/TOPK表达与宫颈癌和宫颈上皮内瘤变密切相关，可能作为肿瘤诊断和免疫治疗的有用靶点。