Chang Chin-Fang, Chen Sung-Lang, Sung Wen-Wei, Hsieh Ming-Ju, Hsu Hui-Ting, Chen Li-Hsin, Chen Mu-Kuan, Ko Jiunn-Liang, Chen Chih-Jung, Chou Ming-Chih
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Department of Otorhinolaryngology, Head and Neck Surgery, Jen-Ai Hospital, Taichung 400, Taiwan.
Int J Mol Sci. 2016 Jun 24;17(7):1007. doi: 10.3390/ijms17071007.
Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.
口腔癌是一种预后较差的常见癌症。我们评估了PBK/TOPK（PDZ结合激酶/T-LAK细胞源蛋白激酶）的表达及其在口腔癌中的预后意义。通过对287例口腔癌患者的样本进行免疫组织化学染色来检测PBK/TOPK的表达。分析PBK/TOPK表达与临床病理特征之间的关联。通过Kaplan-Meier分析和Cox比例风险模型确定PBK/TOPK对总生存期的预后价值。PBK/TOPK高表达水平与较长的总生存期相关。PBK/TOPK表达的预后作用在年轻患者（p<0.05）、有吸烟习惯的患者（p<0.05）和晚期疾病患者（p<0.）中具有显著性。我们的结果表明口腔癌中PBK/TOPK表达增强。高PBK/TOPK表达，无论是单独还是根据临床病理特征分为亚组，都可能作为口腔癌患者的一个良好预后标志物。
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