McKinnon W, Weisse C S, Reynolds C P, Bowles C A, Baum A
Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Health Psychol. 1989;8(4):389-402. doi: 10.1037//0278-6133.8.4.389.
Psychological stress has been shown to affect immune system status and function, but most studies of this relationship have focused on acute stress and/or laboratory situations. The present study compared total numbers of leukocytes and lymphocyte subpopulations (determined by flow cytometry) and antibody titers to latent and nonlatent viruses among a group of chronically stressed individuals living near the damaged Three Mile Island (TMI) nuclear power plant with those of a demographically comparable control group. Urinary catecholamine and cortisol levels were also examined. Residents of the TMI area exhibited greater numbers of neutrophils, which were positively correlated with epinephrine levels. The TMI group also exhibited fewer B lymphocytes, T-suppressor/cytotoxic lymphocytes, and natural killer cells. Antibody titers to herpes simplex were significantly different across groups as well, whereas titers to nonlatent rubella virus as well as IgG and IgM levels were comparable.
心理压力已被证明会影响免疫系统的状态和功能，但大多数关于这种关系的研究都集中在急性应激和/或实验室环境中。本研究比较了居住在受损的三里岛（TMI）核电站附近的一组长期处于压力下的个体与人口统计学上可比的对照组之间的白细胞总数、淋巴细胞亚群（通过流式细胞术测定）以及针对潜伏和非潜伏病毒的抗体滴度。还检测了尿儿茶酚胺和皮质醇水平。TMI地区的居民中性粒细胞数量更多，且与肾上腺素水平呈正相关。TMI组的B淋巴细胞、抑制性/细胞毒性T淋巴细胞和自然杀伤细胞也较少。各组之间单纯疱疹抗体滴度也存在显著差异，而针对非潜伏风疹病毒的滴度以及IgG和IgM水平相当。
