Department of Dermatology, Mustafa Kemal University, Hatay, Turkey.
Turk J Med Sci. 2014;44(6):1051-4.
BACKGROUND/AIM: Vitiligo is a common, acquired depigmenting skin disorder. The relationship between Helicobacter pylori (HP) infection and autoimmune dermatological disease has been previously reported. However, the frequency of HP infection in patients with vitiligo has not been reported. In this study, we aimed to investigate the frequency of HP infection with the carbon 14 (C14) urea breath test (UBT) in patients with vitiligo.
This study included 34 patients (18 males and 16 females) with vitiligo and 30 age- and sex-matched healthy controls. HP infection was diagnosed using the C14 UBT (Heliprobe). Statistical analysis was performed using SPSS 19.
The frequency of HP infection was 64.7% in the patient group and 33.3% in the control group according to the C14 UBT (chi- square test, P = 0.012). HP infection frequency is statistically significantly higher in patients with vitiligo.
To the best of our knowledge, this is the first investigation of the frequency of HP positivity in patients with vitiligo. To better understand the role of HP in vitiligo as an etiological or initiating factor, further experimental and clinical studies with a greater number of patients are needed.
背景/目的：白癜风是一种常见的获得性色素减退性皮肤病。先前已有报道称，幽门螺杆菌（HP）感染与自身免疫性皮肤病之间存在关联。然而，白癜风患者中 HP 感染的频率尚未报道。在本研究中，我们旨在通过 14C 尿素呼气试验（UBT）来调查白癜风患者中 HP 感染的频率。
本研究纳入了 34 名白癜风患者（18 名男性和 16 名女性）和 30 名年龄和性别匹配的健康对照者。采用 Heliprobe 进行 HP 感染的 C14 UBT 诊断。使用 SPSS 19 进行统计分析。
根据 C14 UBT，患者组的 HP 感染频率为 64.7%，对照组为 33.3%（卡方检验，P=0.012）。白癜风患者的 HP 感染频率明显更高。
据我们所知，这是首次对白癜风患者中 HP 阳性率进行的调查。为了更好地理解 HP 在白癜风中作为病因或起始因素的作用，需要进一步进行更多患者的实验和临床研究。
