Department of Gastroenterology, Ankara Training and Research Hospital, Sukriye District, Ulucanlar Street, Altındağ, Ankara 06230, Turkey,
Am J Clin Dermatol. 2014 Oct;15(5):457-62. doi: 10.1007/s40257-014-0087-3.
Helicobacter pylori is a worldwide bacteria that may affect several extra-gastric systems, including the endocrine, hematologic, vascular, respiratory, immune, and skin. Several skin diseases, including chronic urticaria, alopecia areata, psoriasis, and systemic lupus erythematosis have been found to be associated with H. pylori infection.
To our knowledge, there are no data showing an association between H. pylori and vitiligo. Therefore, in this study, we wanted to evaluate the relationship between H. pylori and vitiligo.
This study is a prospective study carried out in our Gastroenterology and Dermatology and Venereology departments of the Ankara Education and Research Hospital (Ankara, Turkey) between July 2013 and December 2013. Seventy-nine consecutive patients with vitiligo and 72 patients with telogen effluvium (TE) were recruited from the dermatology outpatient clinic. A total of 133 patients with vitiligo (n=68) and TE (n=65) [excluding 18 patients who had suspicious urea breath test (UBT) results] were included in the study. All individuals were tested for H. pylori IgG and CagA. Also, a UBT was performed to detect the presence of H. pylori infection.
There were significantly higher rates of H. pylori positivity, H. pylori CagA, and IgG in serum in the vitiligo group than in the TE group (p<0.05). The number of patients with dyspepsia was significantly higher in the vitiligo group than in the TE group. No statistically significant relationship was seen between H. pylori positivity, CagA, H. pylori IgG, dyspepsia, and the Vitiligo Disease Activity score (p>0.05). Also, when patients with vitiligo were divided into localized and generalized types of vitiligo, there was no association between vitiligo involvement pattern and H. pylori positivity, CagA, H. pylori IgG, and dyspepsia (p>0.05).
Additional studies are necessary to evaluate the effect of H. pylori eradication on the clinical course of vitiligo. Further studies are also needed to explain the relationship between H. pylori and the pathogenesis of vitiligo.
幽门螺杆菌是一种全球范围内的细菌，可能会影响到多个胃部以外的系统，包括内分泌、血液、血管、呼吸、免疫和皮肤。已发现多种皮肤疾病，包括慢性荨麻疹、斑秃、银屑病和系统性红斑狼疮与幽门螺杆菌感染有关。
据我们所知，目前尚无数据表明幽门螺杆菌与白癜风之间存在关联。因此，在本研究中，我们希望评估幽门螺杆菌与白癜风之间的关系。
本研究为前瞻性研究，于 2013 年 7 月至 2013 年 12 月在土耳其安卡拉教育与研究医院的胃肠病学和皮肤科及性病科进行。从皮肤科门诊招募了 79 例白癜风患者和 72 例休止期脱发（TE）患者。共有 133 例白癜风患者（n=68）和 TE 患者（n=65）[排除 18 例可疑尿素呼气试验（UBT）结果的患者]纳入研究。所有个体均接受了幽门螺杆菌 IgG 和 CagA 检测。此外，还进行了 UBT 以检测幽门螺杆菌感染情况。
与 TE 组相比，白癜风组的幽门螺杆菌阳性率、CagA 和血清 IgG 水平显著更高（p<0.05）。白癜风组的消化不良患者人数明显多于 TE 组。幽门螺杆菌阳性率、CagA、幽门螺杆菌 IgG、消化不良与白癜风疾病活动评分之间无显著相关性（p>0.05）。此外，当将白癜风患者分为局限性和广泛性白癜风时，白癜风受累模式与幽门螺杆菌阳性率、CagA、幽门螺杆菌 IgG 和消化不良之间无关联（p>0.05）。
需要进一步的研究来评估幽门螺杆菌根除对白癜风临床病程的影响。还需要进一步的研究来解释幽门螺杆菌与白癜风发病机制之间的关系。
