Machumi Francis, Midiwo Jacob O, Jacob Melissa R, Khan Shabana I, Tekwani Babu L, Zhang Jin, Walker Larry A, Muhammad Ilias
National Center for Natural Products Research, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
Nat Prod Commun. 2013 Jul 1;8(6):761-764.
Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plant led to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3--β-D-glucopyranosyl-β-sitosterol. The new compound was identified using spectroscopic methods, notably 1D- and 2D NMR, as 3β,24--ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid. The isolated compounds were evaluated for their antimicrobial and antiplasmodial activities. Two compounds with a galloyl group ( and ) were found to be active against chloroquine sensitive (D6) and chloroquine resistant (W2) strains of , whereas three ellagic acid derivatives (-) were found active against three species of fungi and one species of bacteria.
对一种非洲药用植物茎皮提取物的乙酸乙酯可溶部分进行植物化学研究，分离出一种新的齐墩果烷型三萜类化合物，以及七种已知的三萜类化合物、七种鞣花酸衍生物和3-β-D-吡喃葡萄糖基-β-谷甾醇。通过光谱方法，特别是一维和二维核磁共振，将新化合物鉴定为3β,24-亚乙基-2α,19α-二羟基齐墩果-12-烯-28-酸。对分离出的化合物进行了抗菌和抗疟活性评估。发现两种带有没食子酰基的化合物（和）对氯喹敏感（D6）和氯喹耐药（W2）的疟原虫菌株有活性，而三种鞣花酸衍生物（-）对三种真菌和一种细菌有活性。
