80%甲醇和新鲜（使君子科）树皮水提取物对小鼠的抗疟活性
Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Fresen. (Combretaceae) against in Mice.
作者信息
Biruk Hana, Sentayehu Biruk, Alebachew Yonatan, Tamiru Wondmagegn, Ejigu Abebe, Assefa Solomon
机构信息
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
出版信息
Biochem Res Int. 2020 Jan 22;2020:9749410. doi: 10.1155/2020/9749410. eCollection 2020.
BACKGROUND
Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of in infected mice.
METHODS
A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of against in Swiss albino mice.
RESULTS
The acute toxicity test indicated that both extracts of against < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant ( < 0.001) compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400 mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant (.
CONCLUSION
The present study indicated that hydromethanolic and aqueous bark extracts of possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract. against.
背景
尽管在过去二十年里取得了重大科学进展，但疟疾仍然是一个全球性负担。对现有抗疟药物的耐药性不断增加是抗击疟疾的一项挑战。药用植物是解决这一问题的有前景的新药来源。因此，本研究旨在评估[植物名称]在感染小鼠体内的抗疟原虫活性。
方法
采用4天抑制试验来评估[植物名称]80%甲醇提取物和树皮水提取物对瑞士白化小鼠体内疟原虫的抗疟效果。
结果
[植物名称]的急性毒性试验表明，两种提取物对[疟原虫名称]的半数致死量均>4000 mg/kg，表明与阴性对照相比毒性较低（P<0.001）。80%甲醇提取物在400 mg/kg剂量时表现出最大化学抑制水平（60.2%）。此外，与阴性对照相比，80%甲醇提取物显示出显著差异（P<0.001）。80%甲醇提取物在400 mg/kg剂量时表现出最大化学抑制水平（60.2%）。此外，80%甲醇提取物显示出显著差异（P<0.001）。
结论
本研究表明，[植物名称]的甲醇水提取物和树皮水提取物具有良好的抗疟活性，其中甲醇水提取物的效果更佳。对[疟原虫名称]有效。
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