虎杖中的神经保护萘和黄酮衍生物。
Neuroprotective naphthalene and flavan derivatives from Polygonum cuspidatum.
作者信息
Liu Fu, Li Fu-shuang, Feng Zi-ming, Yang Ya-nan, Jiang Jian-shuang, Li Li, Zhang Pei-cheng
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Phytochemistry. 2015 Feb;110:150-9. doi: 10.1016/j.phytochem.2014.12.007. Epub 2014 Dec 29.
Ten naphthalene derivatives including two unusual glycosides possessing a naphthalene-fused piceid via a [C8'-O-C6-C5-C7']-trans-dihydrofuran ring, two flavan derivatives, as well as sixteen known phenolic compounds, were isolated from Polygonum cuspidatum. The structures were determined by extensive NMR, MS, CD data, and chemical evidence. In the in vitro neuroprotective assays, at the concentration of 10 μM, five of these compounds exhibited significant effects against PC12 cells injured by rotenone.
从虎杖中分离出10种萘衍生物，包括两种不寻常的糖苷，它们通过一个[C8'-O-C6-C5-C7']-反式二氢呋喃环与萘并云杉新苷相连，两种黄烷衍生物，以及16种已知的酚类化合物。通过广泛的核磁共振（NMR）、质谱（MS）、圆二色光谱（CD）数据和化学证据确定了其结构。在体外神经保护试验中，在10 μM的浓度下，其中5种化合物对鱼藤酮损伤的PC12细胞表现出显著的保护作用。
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