Janssen Imke, Powell Lynda H, Jasielec Mateusz S, Kazlauskaite Rasa
Department of Preventive Medicine, Rush University Medical Center, Chicago, IL 60612.
Department of Medicine, Rush University Medical Center, Chicago, IL 60612.
Obesity (Silver Spring). 2015 Feb;23(2):488-494. doi: 10.1002/oby.20974. Epub 2014 Dec 31.
To determine whether menopause-related changes in reproductive hormones were associated with change in adiposity and whether these relationships were independent of important covariates.
Annual assessments of adiposity measures [computed tomography-assessed visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) and dual-energy X-ray absorptiometry-assessed total body fat (TBF)] over 4 years from an ancillary study at the Chicago site of the Study of Women's Health Across the Nation (SWAN) were paired with reproductive hormones collected by SWAN. Included were 243 women (44% African American, 56% Caucasian) who were eligible participants in a population-based cohort with a 72% participation rate.
VAT increased by 3.8% annually, and SAT increased by 1.8% per year. Change in bioavailable testosterone was significantly positively associated with changes both in VAT and in SAT but was not related to change in total body fat. The associations were independent of age, race, physical activity, smoking, baseline TBF, baseline bioavailable testosterone, and change in TBF. Change in estradiol was unrelated to changes in any adiposity measure.
Bioavailable testosterone may play an important role in menopause-related redistribution of visceral and subcutaneous fat in the central abdominal region.
确定生殖激素与绝经相关的变化是否与肥胖变化相关，以及这些关系是否独立于重要的协变量。
对来自全国女性健康研究（SWAN）芝加哥站点一项辅助研究的4年期间的肥胖指标[计算机断层扫描评估的内脏脂肪组织（VAT）和腹部皮下脂肪组织（SAT）以及双能X线吸收法评估的全身脂肪（TBF）]进行年度评估，并与SWAN收集的生殖激素配对。纳入了243名女性（44%为非裔美国人，56%为白种人），她们是一个基于人群的队列中的合格参与者，参与率为72%。
VAT每年增加3.8%，SAT每年增加1.8%。生物可利用睾酮的变化与VAT和SAT的变化均显著正相关，但与全身脂肪的变化无关。这些关联独立于年龄、种族、身体活动、吸烟、基线TBF、基线生物可利用睾酮以及TBF的变化。雌二醇的变化与任何肥胖指标的变化均无关。
生物可利用睾酮可能在绝经相关的腹部中央区域内脏和皮下脂肪重新分布中起重要作用。
