Department of endocrinology, Geriatric Diseases Institute of Chengdu, Center for Medical Research and Translation, Chengdu Fifth People's Hospital, Chengdu, China.
Information center, Chengdu Fifth People's Hospital, Chengdu, China.
J Diabetes. 2024 Jan;16(1):e13472. doi: 10.1111/1753-0407.13472. Epub 2023 Sep 25.
We aim to explore the cumulative predictive value of elevated serum thyroid stimulating hormone (TSH) and visceral fat area (VFA) for metabolic syndrome (MS) development in postmenopausal women.
A total of 1006 postmenopausal females were enrolled in a 10-year prospective longitudinal study from 2011 to 2021 in the community of Banknote Printing Company of Chengdu. The sociodemographic information collection and anthropometric measurements were made by a professional nurse. Fasting blood samples were drawn for chemical analysis of fasting plasma glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and TSH. Magnetic resonance imaging was performed to measure VFA. All the participants were categorized into four groups according to median VFA and serum level of TSH.
A total of 793 postmenopausal females without MS underwent a 10-year follow-up study grouping by TSH and VFA: Group 1 (TSH level <4.2 μIU/mL, and VFA < 70 cm ), Group 2 (TSH level ≥4.2 μIU/mL, and VFA < 70 cm ), Group 3 (TSH level <4.2 μIU/mL, and VFA ≥70 cm ) and Group 4 (TSH level ≥4.2 μIU/mL, and VFA ≥70 cm ). During the 10-year follow-up, MS was newly developed in 326 (41.1%) subjects. The incidence of MS was 29.8% (n = 53), 35.2% (n = 63), 41% (n = 87), and 55% (n = 123) from Group 1 to Group 4 (Group 4 vs other groups, p < .001). Cox regression analysis for MS prediction demonstrated that both TSH (Model 3, hazard ratio [HR] = 1.07 [95% confidence interval, 1.05-1.09]) and VFA (Model 4, HR = 1.02 [95% confidence interval, 1.01-1.08]) were not only independent predictors of MS but also involved some interaction between each other (p for interaction = .021).
Our findings suggested that mutual interaction between higher TSH and VFA contributed to the development of MS. Further studies are needed to clarify these contributions.
我们旨在探讨血清促甲状腺激素（TSH）和内脏脂肪面积（VFA）升高对绝经后妇女代谢综合征（MS）发展的累积预测价值。
2011 年至 2021 年，我们对成都钞票印制公司社区的 1006 名绝经后女性进行了一项为期 10 年的前瞻性纵向研究。专业护士进行了社会人口统计学信息收集和人体测量。抽取空腹血样进行空腹血糖、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和 TSH 的化学分析。磁共振成像（MRI）用于测量 VFA。根据 VFA 和 TSH 的中位数，将所有参与者分为四组。
共有 793 名无 MS 的绝经后女性进行了 TSH 和 VFA 分组的 10 年随访研究：第 1 组（TSH 水平<4.2μIU/mL，且 VFA<70cm）、第 2 组（TSH 水平≥4.2μIU/mL，且 VFA<70cm）、第 3 组（TSH 水平<4.2μIU/mL，且 VFA≥70cm）和第 4 组（TSH 水平≥4.2μIU/mL，且 VFA≥70cm）。在 10 年的随访中，有 326 名（41.1%）受试者新发生 MS。MS 的发生率分别为第 1 组至第 4 组的 29.8%（n=53）、35.2%（n=63）、41%（n=87）和 55%（n=123）（第 4 组与其他组相比，p<0.001）。MS 预测的 Cox 回归分析表明，TSH（模型 3，风险比[HR]=1.07[95%置信区间，1.05-1.09]）和 VFA（模型 4，HR=1.02[95%置信区间，1.01-1.08]）不仅是 MS 的独立预测因素，而且彼此之间存在一些相互作用（p 交互=0.021）。
我们的研究结果表明，较高的 TSH 和 VFA 之间的相互作用有助于 MS 的发生。需要进一步的研究来阐明这些作用。
