从日本一只绿翅鸭中分离出的一种罕见H12N3禽流感病毒的基因特征分析。
Genetic characterization of a rare H12N3 avian influenza virus isolated from a green-winged teal in Japan.
作者信息
Bui Vuong Nghia, Ogawa Haruko, Hussein Islam T M, Hill Nichola J, Trinh Dai Quang, AboElkhair Mohammed, Sultan Serageldeen, Ma Eric, Saito Keisuke, Watanabe Yukiko, Runstadler Jonathan A, Imai Kunitoshi
机构信息
Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido, 080-8555, Japan.
出版信息
Virus Genes. 2015 Apr;50(2):316-20. doi: 10.1007/s11262-014-1162-9. Epub 2015 Jan 4.
This study reports on the genetic characterization of an avian influenza virus, subtype H12N3, isolated from an Eurasian green-winged teal (Anas crecca) in Japan in 2009. The entire genome sequence of the isolate was analyzed, and phylogenetic analyses were conducted to characterize the evolutionary history of the isolate. Phylogenetic analysis of the hemagglutinin and neuraminidase genes indicated that the virus belonged to the Eurasian-like avian lineage. Molecular dating indicated that this H12 virus is likely a multiple reassortant influenza A virus. This is the first reported characterization of influenza A virus subtype H12N3 isolated in Japan and these data contribute to the accumulation of knowledge on the genetic diversity and generation of novel influenza A viruses.
本研究报告了2009年从日本一只欧亚绿翅鸭（Anas crecca）中分离出的H12N3亚型禽流感病毒的基因特征。对该分离株的全基因组序列进行了分析，并进行了系统发育分析以表征该分离株的进化史。血凝素和神经氨酸酶基因的系统发育分析表明，该病毒属于欧亚类禽谱系。分子年代测定表明，这种H12病毒可能是一种多重重配甲型流感病毒。这是日本首次报道的H12N3亚型甲型流感病毒的特征描述，这些数据有助于积累关于甲型流感病毒遗传多样性和新型甲型流感病毒产生的知识。
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