Chou S C, Taylor J D, Tchen T T
Department of Chemistry, Wayne State University, Detroit, Michigan 48202.
Pigment Cell Res. 1989 Sep-Oct;2(5):414-20. doi: 10.1111/j.1600-0749.1989.tb00230.x.
Using a goldfish-derived melanized cell line, we attempted to determine the identity of the signal transduction system/second messenger for epinephrine-induced aggregation of melanosomes in a goldfish cell line. The results show that the second messenger is unknown. It is not 1) influx of extracellular calcium, 2) release of intracellular stored calcium via the phosphoinositide pathway, 3) cGMP, or 4) decrease of cAMP. These results suggest that there is an unknown second messenger for this activity of epinephrine.
利用源自金鱼的黑化细胞系，我们试图确定在金鱼细胞系中肾上腺素诱导黑素体聚集的信号转导系统/第二信使的身份。结果表明，第二信使尚不清楚。它不是1）细胞外钙内流，2）通过磷酸肌醇途径释放细胞内储存的钙，3）环鸟苷酸，也不是4）环磷酸腺苷减少。这些结果表明，肾上腺素的这种活性存在一个未知的第二信使。
