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[职业医学中的过度诊断与防御性医疗]

[Overdiagnosis and defensive medicine in occupational medicine].

作者信息

Berral Alessandro, Pira Enrico, Romano Canzio

机构信息

Associazione Piemontese e Aostana di Medicina del Lavoro.

出版信息

G Ital Med Lav Ergon. 2014 Oct-Dec;36(4):321-31.

Abstract

In clinical medicine since some years overdiagnosis is giving rise to growing attention and concern. Overdiagnosis is the diagnosis of a "disease" that will never cause symptoms or death during a patient's lifetime. It is a side effect of testing for early forms of disease which may turn people into patients unnecessarily and may lead to treatments that do no good and perhaps do harm. Overdiagnosis occurs when a disease is diagnosed correctly, but the diagnosis is irrelevant. A correct diagnosis may be irrelevant because treatment for the disease is not available, not needed, or not wanted. Four drivers engender overdiagnosis: 1) screening in non symptomatic subjects; 2) raised sensitivity of diagnostic tests; 3) incidental overdiagnosis; 4) broadening of diagnostic criteria for diseases. "Defensive medicine" can play a role. It begs the question of whether even in the context of Occupational Medicine overdiagnosis is possible. In relation to the double diagnostic evaluation peculiar to Occupational Medicine, the clinical and the causal, a dual phenomenon is possible: that of overdiagnosis properly said and what we could define the overattribution, in relation to the assessment of a causal relationship with work. Examples of occupational "diseases" that can represent cases of overdiagnosis, with the possible consequences of overtreatment, consisting of unnecessary and socially harmful limitations to fitness for work, are taken into consideration: pleural plaques, alterations of the intervertebral discs, "small airways disease", sub-clinical hearing impairment. In Italy the National Insurance for occupational diseases (INAIL) regularly recognizes less than 50% of the notified diseases; this might suggest overdiagnosis and possibly overattribution in reporting. Physicians dealing with the diagnosis of occupational diseases are obviously requested to perform a careful, up-to-date and active investigation. When applying to the diagnosis of occupational diseases, proper logical criteria should be even antecedent to a good diagnostic technique, due to social outcome for the worker.

摘要

近年来,过度诊断在临床医学中引起了越来越多的关注和担忧。过度诊断是指对一种在患者一生中都不会引起症状或导致死亡的“疾病”做出诊断。它是疾病早期检测的一种副作用,可能会不必要地将人变成患者,并可能导致无益甚至有害的治疗。当一种疾病被正确诊断,但该诊断却不相关时,就会出现过度诊断。正确的诊断可能不相关,因为针对该疾病的治疗无法获得、不需要或不被患者接受。导致过度诊断的四个因素是:1)对无症状受试者进行筛查;2)诊断测试敏感性提高;3)偶然的过度诊断;4)疾病诊断标准的扩大。“防御性医疗”也可能起作用。这就引出了一个问题,即在职业医学领域是否也可能存在过度诊断。就职业医学特有的双重诊断评估而言,即临床诊断和因果关系诊断,可能会出现双重现象:一种是严格意义上的过度诊断,另一种是我们可以定义为过度归因的情况,这与工作因果关系的评估有关。考虑到一些职业“疾病”可能代表过度诊断的案例,以及过度治疗可能带来的后果,包括对工作适应性造成不必要的且对社会有害的限制,例如胸膜斑、椎间盘退变、“小气道疾病”、亚临床听力损伤。在意大利,国家职业病保险(INAIL)通常认可的职业病申报病例不到50%;这可能表明在申报中存在过度诊断甚至过度归因的情况。显然,从事职业病诊断的医生需要进行仔细、最新且积极的调查。由于对工人的社会影响,在应用于职业病诊断时,恰当的逻辑标准甚至应先于良好的诊断技术。

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