Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Nat Neurosci. 2015 Feb;18(2):289-94. doi: 10.1038/nn.3909. Epub 2015 Jan 5.
Hippocampal information processing is discretized by oscillations, and the ensemble activity of place cells is organized into temporal sequences bounded by theta cycles. Theta sequences represent time-compressed trajectories through space. Their forward-directed nature makes them an intuitive candidate mechanism for planning future trajectories, but their connection to goal-directed behavior remains unclear. As rats performed a value-guided decision-making task, the extent to which theta sequences projected ahead of the animal's current location varied on a moment-by-moment basis depending on the rat's goals. Look-ahead extended farther on journeys to distant goals than on journeys to more proximal goals and was predictive of the animal's destination. On arrival at goals, however, look-ahead was similar regardless of where the animal began its journey from. Together, these results provide evidence that hippocampal theta sequences contain information related to goals or intentions, pointing toward a potential spatial basis for planning.
海马体的信息处理是离散的，通过θ波震荡，位置细胞的整体活动被组织成由θ波周期限定的时间序列。θ波序列代表了通过空间的时间压缩轨迹。它们的前向性质使它们成为规划未来轨迹的直观候选机制，但它们与目标导向行为的联系仍不清楚。当老鼠执行一个有价值的决策任务时，θ波序列在动物当前位置之前的预测程度会根据老鼠的目标在瞬间发生变化。对于遥远目标的旅程，前瞻性延伸得更远，而对于更接近目标的旅程则更短，并且可以预测动物的目的地。然而，当到达目标时，无论动物从哪里开始旅程，前瞻性都是相似的。这些结果共同证明了海马体θ波序列包含与目标或意图相关的信息，为规划提供了潜在的空间基础。
