Dash Biraja C, Jiang Zhengxin, Suh Carol, Qyang Yibing
*Department of Internal Medicine, Section of Cardiovascular Medicine, School of Medicine, Yale University, New Haven, CT 06250, U.S.A.
Biochem J. 2015 Jan 15;465(2):185-94. doi: 10.1042/BJ20141078.
Vascular smooth muscle cells (VSMCs) play a major role in the pathophysiology of cardiovascular diseases. The advent of induced pluripotent stem cell (iPSC) technology and the capability of differentiating into virtually every cell type in the human body make this field a ray of hope for vascular regenerative therapy and understanding of the disease mechanism. In the present review, we first discuss the recent iPSC technology and vascular smooth muscle development from an embryo and then examine different methodologies to derive VSMCs from iPSCs, and their applications in regenerative therapy and disease modelling.
血管平滑肌细胞(VSMCs)在心血管疾病的病理生理学中起主要作用。诱导多能干细胞(iPSC)技术的出现以及分化为人体几乎每种细胞类型的能力,使该领域成为血管再生治疗和疾病机制理解的一线希望。在本综述中,我们首先讨论了最近的iPSC技术以及胚胎中的血管平滑肌发育,然后研究了从iPSC中获得VSMCs的不同方法,以及它们在再生治疗和疾病建模中的应用。