骨骼的进化生理学：变化环境中的骨骼代谢。

Evolutionary physiology of bone: bone metabolism in changing environments.

机构信息

Department of Mechanical Engineering, Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado; and.

Department of Biology and Graduate Degree Program in Ecology, Colorado State University, Fort Collins, Colorado.

出版信息

Physiology (Bethesda). 2015 Jan;30(1):17-29. doi: 10.1152/physiol.00022.2014.

DOI:10.1152/physiol.00022.2014

PMID:25559152

Abstract

Bone evolved to serve many mechanical and physiological functions. Osteocytes and bone remodeling first appeared in the dermal skeleton of fish, and subsequently adapted to various challenges in terrestrial animals occupying diverse environments. This review discusses the physiology of bone and its role in mechanical and calcium homeostases from an evolutionary perspective. We review how bone physiology responds to changing environments and the adaptations to unique and extreme physiological conditions.

摘要

骨骼进化以服务于多种机械和生理功能。骨细胞和骨重塑首先出现在鱼类的皮肤骨骼中，随后适应了在不同环境中生活的陆地动物的各种挑战。本综述从进化的角度讨论了骨骼生理学及其在机械和钙稳态中的作用。我们回顾了骨骼生理学如何响应不断变化的环境以及对独特和极端生理条件的适应。