Hospital of Stomatology, Jilin University, Changchun, China.
The School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
Front Endocrinol (Lausanne). 2023 Sep 19;14:1217579. doi: 10.3389/fendo.2023.1217579. eCollection 2023.
Bone is a dynamic organ that, once formed, undergoes a constant remodeling process that includes bone resorption and synthesis. Osteoclasts and osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), a transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed that XBP1 plays a vital role in bone metabolism, including osteoclast and osteoblast development, as well as in regulating immune cell differentiation that affects the immune microenvironment of bone remodeling. In this review, we highlight the regulatory mechanisms of XBP1 on osteoclasts and osteoblasts, how XBP1 affects the immune microenvironment of bone remodeling by influencing the differentiation of immune cells, and predict the possible future research directions of XBP1 to provide new insights for the treatment of bone-related metabolic diseases.
骨是一种动态器官，一旦形成，就会经历一个包括骨吸收和合成的不断重塑过程。破骨细胞和成骨细胞主要负责控制这个过程。X 盒结合蛋白 1（XBP1）是一种转录因子，以多种方式影响骨骼代谢。近年来，大量研究表明，XBP1 在骨代谢中起着至关重要的作用，包括破骨细胞和成骨细胞的发育，以及调节影响骨重塑免疫微环境的免疫细胞分化。在这篇综述中，我们强调了 XBP1 对破骨细胞和成骨细胞的调节机制，以及 XBP1 通过影响免疫细胞的分化如何影响骨重塑的免疫微环境，并预测了 XBP1 未来可能的研究方向，为治疗与骨相关的代谢性疾病提供新的见解。
