新变种兔出血症病毒（RHDV）正在葡萄牙野兔种群中取代基因群1吗？
Is the new variant RHDV replacing genogroup 1 in Portuguese wild rabbit populations?
作者信息
Lopes Ana M, Correia Jorge, Abrantes Joana, Melo Pedro, Ramada Margarida, Magalhães Maria J, Alves Paulo C, Esteves Pedro J
机构信息
CIBIO, InBIO-Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661 Vairão, Portugal.
CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal.
出版信息
Viruses. 2014 Dec 30;7(1):27-36. doi: 10.3390/v7010027.
The Lagovirus rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae, severely affects European rabbit (Oryctolagus cuniculus) populations by causing rabbit hemorrhagic disease (RHD). RHDV is subdivided in six genogroups but, more recently, a new RHDV variant with a unique genetic and antigenic profile emerged. We performed a study in rabbits found dead in the field during 2013 and 2014 in Portugal to determine the prevalence of this new variant versus the classical RHDV. Fifty-seven liver samples were screened for the presence of RHDV and positive samples were genotyped. All cases of RHDV infection were caused by the new variant. The only former genogroup circulating in Portugal, G1, was not detected. We hence conclude that the new RHDV variant is replacing G1 in Portugal, probably due to a selective advantage. This sudden and rapid replacement emphasizes the necessity of continued monitoring of wild rabbit populations.
兔出血症病毒（RHDV）属于杯状病毒科，通过引发兔出血症（RHD）严重影响欧洲兔（穴兔）种群。RHDV可细分为六个基因群，但最近出现了一种具有独特遗传和抗原特征的新型RHDV变种。我们对2013年和2014年在葡萄牙野外发现死亡的兔子进行了一项研究，以确定这种新变种与经典RHDV的流行情况。对57份肝脏样本进行了RHDV检测，对阳性样本进行了基因分型。所有RHDV感染病例均由新变种引起。在葡萄牙唯一曾流行的基因群G1未被检测到。因此，我们得出结论，新的RHDV变种正在取代葡萄牙的G1基因群，这可能是由于其具有选择性优势。这种突然而迅速的取代凸显了持续监测野兔种群的必要性。
Zotero 插件