Center for Neuro-Oncology, Dana-Farber/Brigham &Women's Cancer Center, 450 Brookline Avenue, Boston, MA 02215, USA.
Nat Rev Clin Oncol. 2015 Feb;12(2):69-70. doi: 10.1038/nrclinonc.2014.223. Epub 2015 Jan 6.
Heterogeneity within and across tumours is increasingly recognized as a critical factor that limits therapeutic progress for many cancers. Key studies reported in 2014 describe previously unappreciated patterns of geographical and temporal heterogeneity for glioblastoma (the most-common primary CNS tumour in adults), with important implications for ongoing therapeutic studies evaluating molecular targeted therapies.
肿瘤内和肿瘤间的异质性正日益被视为限制许多癌症治疗进展的关键因素。2014 年报告的重要研究描述了胶质母细胞瘤（成人中最常见的原发性 CNS 肿瘤）以前未被认识到的地理和时间异质性模式，这对正在进行的评估分子靶向治疗的治疗研究具有重要意义。
