喹诺酮类药物对大肠杆菌DNA回旋酶及胎牛胸腺拓扑异构酶II的抑制作用。
Inhibitory effects of quinolones on DNA gyrase of Escherichia coli and topoisomerase II of fetal calf thymus.
作者信息
Hoshino K, Sato K, Une T, Osada Y
机构信息
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1989 Oct;33(10):1816-8. doi: 10.1128/AAC.33.10.1816.
Abstract
The in vitro inhibitory effects of quinolones on the bacterial DNA gyrase of Escherichia coli KL-16 and topoisomerase II of fetal calf thymus were compared. All the quinolones tested required higher concentrations to inhibit the topoisomerase II than to inhibit the DNA gyrase, and no correlation existed among their inhibitory activities against both enzymes. However, there was a large difference among the quinolones in their selectivities between the bacterial enzyme and its eucaryotic counterpart. The selectivity of ofloxacin was highest, and the selectivities of CI-934 and nalidixic acid were lowest.
摘要
比较了喹诺酮类药物对大肠杆菌KL-16的细菌DNA促旋酶和胎牛胸腺拓扑异构酶II的体外抑制作用。所有测试的喹诺酮类药物抑制拓扑异构酶II所需的浓度均高于抑制DNA促旋酶所需的浓度，且它们对这两种酶的抑制活性之间不存在相关性。然而，喹诺酮类药物在细菌酶与其真核对应物之间的选择性存在很大差异。氧氟沙星的选择性最高，CI-934和萘啶酸的选择性最低。
相似文献
1
Inhibitory effects of quinolones on DNA gyrase of Escherichia coli and topoisomerase II of fetal calf thymus.喹诺酮类药物对大肠杆菌DNA回旋酶及胎牛胸腺拓扑异构酶II的抑制作用。
Antimicrob Agents Chemother. 1989 Oct;33(10):1816-8. doi: 10.1128/AAC.33.10.1816.
2
Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases.氧氟沙星衍生物恶嗪环上甲基在抑制细菌和哺乳动物II型拓扑异构酶中的意义。
Antimicrob Agents Chemother. 1991 Feb;35(2):309-12. doi: 10.1128/AAC.35.2.309.
3
Inhibitory effects of quinolones on pro- and eucaryotic DNA topoisomerases I and II.喹诺酮类药物对原核和真核DNA拓扑异构酶I和II的抑制作用。
Antimicrob Agents Chemother. 1990 Oct;34(10):1955-60. doi: 10.1128/AAC.34.10.1955.
4
Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition.喹诺酮类药物对大肠杆菌拓扑异构酶IV的抑制作用与对DNA旋转酶抑制作用的比较。
Antimicrob Agents Chemother. 1994 Nov;38(11):2623-7. doi: 10.1128/AAC.38.11.2623.
5
Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I.DNA回旋酶抑制剂培氟沙星、其他五种喹诺酮类药物、新生霉素和氯新生霉素对大肠杆菌拓扑异构酶I的影响。
Antimicrob Agents Chemother. 1987 Dec;31(12):1925-8. doi: 10.1128/AAC.31.12.1925.
6
Inhibitory effects of quinolones on murine hematopoietic progenitor cells and eukaryotic topoisomerase II.喹诺酮类药物对小鼠造血祖细胞和真核拓扑异构酶II的抑制作用。
Chemotherapy. 1991;37(3):224-6. doi: 10.1159/000238858.
7
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.新型氟喹诺酮类药物加替沙星（AM-1155）对细菌和哺乳动物II型拓扑异构酶的抑制活性。
Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81. doi: 10.1128/AAC.42.10.2678.
8
Sequence analysis, purification, and study of inhibition by 4-quinolones of the DNA gyrase from Mycobacterium smegmatis.耻垢分枝杆菌DNA回旋酶的序列分析、纯化及4-喹诺酮类药物对其抑制作用的研究。
Antimicrob Agents Chemother. 1996 Sep;40(9):2054-61. doi: 10.1128/AAC.40.9.2054.
9
Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV of Enterococcus faecalis.喹诺酮类药物对粪肠球菌DNA回旋酶和拓扑异构酶IV的抑制活性。
Antimicrob Agents Chemother. 2002 Jun;46(6):1800-4. doi: 10.1128/AAC.46.6.1800-1804.2002.
10
Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases.金黄色葡萄球菌和大肠杆菌II型DNA拓扑异构酶的差异行为
Antimicrob Agents Chemother. 1996 Dec;40(12):2714-20. doi: 10.1128/AAC.40.12.2714.
引用本文的文献
1
Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents.喹诺酮类的生物学效应：一类广谱抗菌药物。
Molecules. 2021 Nov 25;26(23):7153. doi: 10.3390/molecules26237153.
2
A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.一种“双刃剑”支架：抗菌喹诺酮类药物中的抗肿瘤作用
Curr Med Chem. 2016;23(6):520-77. doi: 10.2174/0929867323666151223095839.
3
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.新型螺嘧啶三酮AZD0914对淋病奈瑟菌II型拓扑异构酶的抑制作用
J Biol Chem. 2015 Aug 21;290(34):20984-20994. doi: 10.1074/jbc.M115.663534. Epub 2015 Jul 6.
4
Management of levofloxacin induced anaphylaxis and acute delirium in a palliative care setting.姑息治疗环境中左氧氟沙星诱发过敏反应和急性谵妄的处理
Indian J Palliat Care. 2015 Jan-Apr;21(1):76-8. doi: 10.4103/0973-1075.150194.
5
Genomics and antimicrobial drug discovery.基因组学与抗菌药物发现
Antimicrob Agents Chemother. 1999 Mar;43(3):439-46. doi: 10.1128/AAC.43.3.439.
6
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.新型氟喹诺酮类药物加替沙星（AM-1155）对细菌和哺乳动物II型拓扑异构酶的抑制活性。
Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81. doi: 10.1128/AAC.42.10.2678.
7
Antibacterial activities and inhibitory effects of sitafloxacin (DU-6859a) and its optical isomers against type II topoisomerases.司帕沙星（DU-6859a）及其光学异构体对II型拓扑异构酶的抗菌活性和抑制作用。
Antimicrob Agents Chemother. 1998 May;42(5):1284-7. doi: 10.1128/AAC.42.5.1284.
8
Attenuation of gentamicin-induced nephrotoxicity in rats by fleroxacin.氟罗沙星对庆大霉素诱导的大鼠肾毒性的减轻作用。
Antimicrob Agents Chemother. 1997 Jun;41(6):1237-45. doi: 10.1128/AAC.41.6.1237.
9
Mechanism of differential activities of ofloxacin enantiomers.氧氟沙星对映体的差异活性机制。
Antimicrob Agents Chemother. 1996 Aug;40(8):1775-84. doi: 10.1128/AAC.40.8.1775.
10
Classification and structure-activity relationships of fluoroquinolones.
Drugs. 1995;49 Suppl 2:16-28. doi: 10.2165/00003495-199500492-00005.
本文引用的文献
1
Purification and characterization of Xenopus laevis topoisomerase II.非洲爪蟾拓扑异构酶II的纯化与特性分析
EMBO J. 1983;2(8):1303-8. doi: 10.1002/j.1460-2075.1983.tb01585.x.
2
In vitro and in vivo activity of DL-8280, a new oxazine derivative.新型恶嗪衍生物DL-8280的体外和体内活性
Antimicrob Agents Chemother. 1982 Oct;22(4):548-53. doi: 10.1128/AAC.22.4.548.
3
DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.来自黑腹果蝇的DNA拓扑异构酶II。超螺旋DNA的松弛
J Biol Chem. 1983 Aug 10;258(15):9536-43.
4
DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.黑腹果蝇的DNA拓扑异构酶II。纯化与物理特性分析。
J Biol Chem. 1983 Aug 10;258(15):9530-5.
5
DNA topoisomerases from rat liver: physiological variations.大鼠肝脏中的DNA拓扑异构酶：生理变异
Nucleic Acids Res. 1983 Feb 25;11(4):1059-75. doi: 10.1093/nar/11.4.1059.
6
7
DNA gyrase: affinity chromatography on novobiocin-Sepharose and catalytic properties.DNA 回旋酶：新生霉素 - 琼脂糖亲和层析及催化特性
Nucleic Acids Res. 1981 Aug 11;9(15):3589-603. doi: 10.1093/nar/9.15.3589.
8
The intrinsic ATPase of DNA gyrase.DNA 回旋酶的内在 ATP 酶
J Biol Chem. 1980 Jul 10;255(13):6299-306.
9
In vitro and in vivo antibacterial activity of AT-2266.AT-2266的体外和体内抗菌活性
Antimicrob Agents Chemother. 1983 Jul;24(1):78-84. doi: 10.1128/AAC.24.1.78.
10
In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.新型喹啉衍生物Bay 09867与其他抗菌药物的体外活性比较。
Antimicrob Agents Chemother. 1983 Apr;23(4):559-64. doi: 10.1128/AAC.23.4.559.
Zotero 插件