Karbasi-Afshar Reza, Saburi Amin, Khedmat Hossein
Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. ; Department of Cardiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
J Tehran Heart Cent. 2014 Jan 12;9(1):1-8.
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States and other industrialized countries, and the reported prevalence in the developing countries is also rather high. This disease is associated with a high rate of morbidity and mortality and damage to the other organs. The cardiovascular system is, perhaps, the most vulnerable organ to NAFLD adverse effects to the extent that most mortality associated with this disease is reportedly from the cardiovascular system rather than from the liver itself. In this article, we review the significant aspects of cardiovascular disorders associated with NAFLD, including the epidemiology of cardiovascular diseases in NAFLD patients, factors that interfere in this relationship like hypertension, severity of NAFLD, and age of the patients, and finally preventive strategies whose employment could significantly improve the outcome.
非酒精性脂肪性肝病（NAFLD）是美国和其他工业化国家慢性肝病的主要病因，据报道，发展中国家的患病率也相当高。这种疾病与高发病率、高死亡率以及对其他器官的损害相关。心血管系统可能是受NAFLD不良影响最脆弱的器官，据报道，与该疾病相关的大多数死亡是由心血管系统而非肝脏本身造成的。在本文中，我们综述了与NAFLD相关的心血管疾病的重要方面，包括NAFLD患者心血管疾病的流行病学、像高血压、NAFLD严重程度和患者年龄等干扰这种关系的因素，以及最终可显著改善预后的预防策略。
