Goh Seok-Chin, Ho Evelyn Lai-Ming, Goh Khean-Lee
Sime Darby Specialist Center Megah, 47400, Petaling Jaya, Malaysia.
Head of Gastroenterology and Hepatology, Department of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Hepatol Int. 2013 Jun;7(2):548-54. doi: 10.1007/s12072-012-9359-2. Epub 2012 Mar 23.
The prevalence of non-alcoholic fatty liver disease (NAFLD) in the Malaysian population is not known. Malaysia has a multiracial Asian population with three major Asian races: Malay, Chinese, and Indian living together. The aim of the study is to determine the prevalence and risk factors in a suburban Malaysian population.
Consecutive subjects who came for a health checkup at a suburban medical facility were recruited for the study. All individuals had clinical assessments, anthropometric measurements, blood tests, and ultrasonography of the liver performed. Those with significant alcohol consumption and history of chronic liver disease were excluded.
Of the 1,621 "health screened" individuals analyzed, 368 (22.7 %) were found to have NAFLD. They comprised Chinese 1,269 (78.3 %), Malay 197 (12.1 %), and Indian 155 (9.6 %). Males and "older" age group ≥45 years had high prevalence rates with the highest in Indian (68.2 %) and Malay (64.7 %) males. Chinese females <45 years had the lowest prevalence of 5.2 %. A significant increase in the prevalence of fatty liver between age <45 years and ≥45 years was seen in female of all three races but in male, this increase was seen only among the Indians. NAFLD was strongly associated with diabetes mellitus, glucose intolerance, body mass index ≥23, low high-density lipoprotein cholesterol, hypertriglyceridemia, and hypertension.
NAFLD is common in suburban Malaysian population. Older Indian and Malay males have an inordinately high prevalence of the disease.
马来西亚人群中非酒精性脂肪性肝病（NAFLD）的患病率尚不清楚。马来西亚是一个多民族的亚洲国家，有马来、华人和印度这三个主要亚洲种族共同生活。本研究的目的是确定马来西亚郊区人群中的患病率及危险因素。
招募到郊区医疗设施进行健康检查的连续受试者参与本研究。所有个体均进行了临床评估、人体测量、血液检查以及肝脏超声检查。排除有大量饮酒史和慢性肝病病史的个体。
在分析的1621名“健康筛查”个体中，发现368人（22.7%）患有NAFLD。其中华人1269人（78.3%），马来人197人（12.1%），印度人155人（9.6%）。男性和年龄≥45岁的“老年”组患病率较高，印度男性（68.2%）和马来男性（64.7%）患病率最高。年龄<45岁的华人女性患病率最低，为5.2%。所有三个种族的女性在年龄<45岁和≥45岁之间脂肪肝患病率均显著增加，但男性中，仅印度男性出现这种增加。NAFLD与糖尿病、葡萄糖耐量异常、体重指数≥23、低高密度脂蛋白胆固醇、高甘油三酯血症和高血压密切相关。
NAFLD在马来西亚郊区人群中很常见。老年印度男性和马来男性该疾病的患病率极高。
