Varenina Ivana, Bilandžić Nina, Cvetnić Luka, Kos Blaženka, Božić Đurđica, Solomun Kolanović Božica, Cvetnić Željko
a Laboratory for Residue Control, Department for Veterinary Public Health , Croatian Veterinary Institute , Zagreb , Croatia.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(3):324-32. doi: 10.1080/19440049.2014.1003104. Epub 2015 Jan 30.
The coccidiostat maduramicin has been approved as a feed additive for chickens and turkeys, although it is prohibited for use in laying hens. In the present study, laying hens were divided into three groups and fed for 14 days with medicated feed containing maduramicin, at three different concentrations: 50, 100 and 500 µg kg(-1). Eggs were collected during treatment and for 26 days after the end of feeding with medicated feed. Maduramicin residues were found exclusively in egg yolk, with the highest concentration in egg yolk of 459 µg kg(-1) for the highest dose. The maximum concentration of maduramicin in whole egg was 16.6 µg kg(-1) for the group receiving feed containing the maximum permitted level of maduramicin in feed (50 µg kg(-1)). The half-life of elimination of maduramicin, calculated for post-treatment days 1-10, was 6.5 days. Twelve days after drug administration, the concentration of the maduramicin in egg yolk for Group 3 (fed with 500 µg kg(-1) maduramicin) still exceeded 20 µg kg(-1), while the concentrations for Groups 1 and 2 were 1.2 and 2.7 µg kg(-1), respectively.
抗球虫药马杜霉素已被批准用作鸡和火鸡的饲料添加剂，不过禁止用于蛋鸡。在本研究中，将蛋鸡分为三组，用含有三种不同浓度（50、100和500微克/千克）马杜霉素的加药饲料喂养14天。在处理期间以及在用加药饲料喂养结束后的26天内收集鸡蛋。仅在蛋黄中发现马杜霉素残留，最高剂量组蛋黄中的最高浓度为459微克/千克。对于接受含有饲料中马杜霉素最大允许水平（50微克/千克）的饲料的组，全蛋中马杜霉素的最大浓度为16.6微克/千克。计算治疗后第1 - 10天马杜霉素的消除半衰期为6.5天。给药12天后，第3组（用500微克/千克马杜霉素喂养）蛋黄中的马杜霉素浓度仍超过20微克/千克，而第1组和第2组的浓度分别为1.2微克/千克和2.7微克/千克。
