鼻病毒3C蛋白酶底物水解的共有序列。
A consensus sequence for substrate hydrolysis by rhinovirus 3C proteinase.
作者信息
Long A C, Orr D C, Cameron J M, Dunn B M, Kay J
机构信息
Dept. of Biochemistry, University of Wales College of Cardiff.
出版信息
FEBS Lett. 1989 Nov 20;258(1):75-8. doi: 10.1016/0014-5793(89)81619-9.
PMID:2556299
Abstract
Kinetic constants were determined for the hydrolysis of a series of synthetic peptide substrates by recombinant rhinovirus (HRV 14) 3C proteinase. Systematic removal or replacement of individual residues indicated that the minimum sequence required for effective cleavage by the viral cysteine proteinase was P5-Val/Thr-P3-P2-Gln-Gly-Pro.
摘要
测定了重组鼻病毒（HRV 14）3C蛋白酶对一系列合成肽底物的水解动力学常数。对单个残基进行系统性去除或替换表明，病毒半胱氨酸蛋白酶有效切割所需的最小序列为P5-缬氨酸/苏氨酸-P3-P2-谷氨酰胺-甘氨酸-脯氨酸。
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