Jee Donghyun, Kim Kyu Seop, Lee Won Ki, Kim Wungjae, Jeon Sohee
a Department of Ophthalmology , St. Vincent's Hospital, College of Medicine, The Catholic University of Korea , Suwon , Gyeonggi-do , Korea .
b Department of Ophthalmology , Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea .
Ocul Immunol Inflamm. 2016;24(2):207-16. doi: 10.3109/09273948.2014.994783. Epub 2015 Jan 7.
To investigate the clinical characteristics and treatment results of adult patients with ocular toxocariasis.
A total of 54 consecutive patients who were clinically and serologically diagnosed with ocular toxocariasis were retrospectively reviewed.
Among patients, 66.7 and 77.3% showed increases in eosinophil cationic protein (ECP) and total Ig E in serum, respectively. Four eyes (7.2%) initially presented as neuroretinitis with subsequent motile retinal lesion. The recurrence rates in the combination treatment group with albendazole and corticosteroids were significantly lower than those in the steroid-alone group during the mean follow-up of 27.6 months (p = 0.001).
The adjunctive test of serum total IgE level may be helpful for the diagnosis of ocular toxocariasis. Ocular toxocariasis should be considered in the differential diagnosis of unilateral neuroretinitis with subsequent motile retinal lesion. Combined treatment with albendazole and corticosteroids appeared to be effective for reducing the recurrence of intraocular inflammation.
探讨成人眼弓蛔虫病的临床特征及治疗效果。
回顾性分析54例经临床和血清学诊断为眼弓蛔虫病的连续患者。
患者中，血清嗜酸性粒细胞阳离子蛋白（ECP）和总IgE升高者分别占66.7%和77.3%。4只眼（7.2%）最初表现为视神经视网膜炎，随后出现视网膜活动病变。在平均27.6个月的随访期间，阿苯达唑和皮质类固醇联合治疗组的复发率显著低于单独使用类固醇组（p = 0.001）。
血清总IgE水平的辅助检测可能有助于眼弓蛔虫病的诊断。在单侧视神经视网膜炎伴随后续视网膜活动病变的鉴别诊断中应考虑眼弓蛔虫病。阿苯达唑和皮质类固醇联合治疗似乎对减少眼内炎症复发有效。
