偶氮二甲酸酯衍生物上氟烷基的亲电胺化反应。

Electrophilic amination of fluoroalkyl groups on azodicarboxylate derivatives.

作者信息

Mamone Marius, Morvan Estelle, Milcent Thierry, Ongeri Sandrine, Crousse Benoit

机构信息

Univ Paris-Sud, BioCIS, CNRS , Faculté de Pharmacie, LabEx LERMIT, 5 rue J-B. Clément, 92290 Châtenay-Malabry, France.

出版信息

J Org Chem. 2015 Feb 6;80(3):1964-71. doi: 10.1021/jo502638y. Epub 2015 Jan 16.

DOI:10.1021/jo502638y

PMID:25565083

Abstract

The formation of an NCF3 bond or an NCF2R bond still remains scarce. An efficient direct electrophilic amination of fluoroalkyl groups was developed. Difluoroenoxysilanes reacted easily on azodicarboxylate derivatives. These results led to a novel family of NCF3 and NCF2 hydrazine derivatives.

摘要

NCF3键或NCF2R键的形成仍然很少见。人们开发了一种氟代烷基的高效直接亲电胺化反应。二氟烯氧基硅烷很容易与偶氮二羧酸酯衍生物发生反应。这些结果产生了一个新的NCF3和NCF2肼衍生物家族。