Sousa Flávia, Castro Pedro, Fonte Pedro, Sarmento Bruno
CESPU, IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra-PRD, Portugal.
Ther Deliv. 2015 Jan;6(1):83-94. doi: 10.4155/tde.14.82.
Non-invasive insulin delivery systems have potential to overcome the most pressing problem regarding effective treatment of diabetic patients: therapy compliance. To overcome this disadvantage, non-invasive routes such as oral, buccal, pulmonary, nasal and transdermal have been proposed. These new routes of insulin administration may help to suppress hypoglycemia episodes and aid to control weight gain and post-meal glucose. Despite all efforts the invasive route remains preferential, since studies on insulin administration by non-invasive routes conducted to date have not demonstrated clinical efficacy and safety, including some products introduced in the market. Therefore, the aim of this review is to make an update of the current state of administration of insulin by non-invasive routes as alternatives to the conventional invasive route.
治疗依从性。为克服这一缺点，已提出口服、颊部、肺部、鼻腔和透皮等非侵入性给药途径。这些胰岛素给药的新途径可能有助于抑制低血糖发作，并有助于控制体重增加和餐后血糖。尽管付出了所有努力，但侵入性途径仍然是首选，因为迄今为止进行的关于非侵入性途径胰岛素给药的研究尚未证明其临床疗效和安全性，包括市场上推出的一些产品。因此，本综述的目的是更新胰岛素非侵入性给药途径作为传统侵入性途径替代方法的当前状态。
