Materials Science Postgraduate Program, Araguaia University Campus, Federal University of Mato Grosso, BR-070, Km 5, 78600-000 Barra do Garças, MT, Brazil.
Biomed Res Int. 2013;2013:541018. doi: 10.1155/2013/541018. Epub 2012 Dec 27.
Natural product incorporation into microcarriers increases the bioavailability of these compounds, consequently improving their therapeutic properties. Natural products, particularly those from bees such as propolis, are widely used in popular medicine. Propolis is a powerful treatment for several diseases. In this context, the present study evaluated the effect of propolis Scaptotrigona sp. and its fractions, alone or adsorbed to polyethylene glycol (PEG) microspheres, on the activity of human phagocytes against Candida albicans. The results show that propolis exerts a stimulatory effect on these cells to assist in combating the fungus, especially as the crude extract is compared with the fractions. However, when incorporated into microspheres, these properties were significantly potentiated. These results suggest that propolis adsorbed onto PEG microspheres has immunostimulatory effects on phagocytes in human blood. Therefore, propolis may potentially be an additional natural product that can be used for a variety of therapies.
天然产物的加入增加了这些化合物的生物利用度，从而改善了它们的治疗特性。天然产物，特别是来自蜜蜂的产物，如蜂胶，在民间医学中被广泛使用。蜂胶是治疗多种疾病的有效药物。在这种情况下，本研究评估了 Scaptotrigona sp.蜂胶及其各馏分单独或吸附到聚乙二醇（PEG）微球上对人吞噬细胞对抗白色念珠菌活性的影响。结果表明，蜂胶对这些细胞具有刺激作用，有助于对抗真菌，尤其是与粗提取物相比时。然而，当被包裹到微球中时，这些特性得到了显著增强。这些结果表明，吸附到 PEG 微球上的蜂胶对人血液中的吞噬细胞具有免疫刺激作用。因此，蜂胶可能是一种潜在的可用于多种治疗方法的天然产物。
