[碳纳米颗粒在青年乳头状甲状腺癌手术中的临床应用]

[Clinical application of carbon nanoparticles in surgery for papillary thyroid carcinoma in young patients].

作者信息

Deng Weiye, Li Hao, Chen Yanfeng, Gao Yunfei, Huang Haiyan, Lin Shaojian, Wang Jianwei, Guo Zhuming

机构信息

Department of Head and Neck Surgery, SUN Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Oct;49(10):812-6.

PMID:25567435

Abstract

OBJECTIVE

To investigate the number of dissected lymph nodes and the incidence of injury to parathyroid glands during surgery for papillary thyroid carcinoma (DTC) in young patients.

METHODS

This study collected clinicopathological data of 51 young patients with PTC. Of the 51 patients, 18 patients were classified into carbon nanoparticles group (CNP group) and 33 patients into traditional surgical group (TS group). The number of dissected lymph nodes and the incidence of injury to parathyroid glands were analyzed using Wilcoxon rank sum test and chi-square test.

RESULTS

There were 16 males and 35 females, with a male/female ratio of 1: 2.19. The age ranged from 14 to 29 (25 ± 3.9) years. There was no statistically significant difference in age, gender, T-classification, TNM stage and surgical procedures between two groups (P > 0.05). The total number of dissected lymph nodes in CNP group was higher than that in TS group (Z = -2.258, P < 0.05) . However, significant difference in the total number of metastatic lymph nodes between the two groups was not found (Z = -0.396, P > 0.05). In level VI, the detected lymph node number of group CNP was higher than that of TS group (Z = -2.461, P < 0.05) but there was no significant difference in the detected number of metastatic lymph nodes (Z = -1.396, P > 0.05) . The rates of injury to parathyroid gland were 5.5% in CNP group and 18.2% in TS group, respectively (χ(2) = 1.568, P > 0.05).

CONCLUSION

Carbon nanoparticles could be an effective lymph nodes tracer applying to PTC operation in young patients.

摘要

目的

探讨青年乳头状甲状腺癌（DTC）患者手术中清扫淋巴结数量及甲状旁腺损伤发生率。

方法

本研究收集了51例青年PTC患者的临床病理资料。51例患者中，18例患者分为碳纳米颗粒组（CNP组），33例患者分为传统手术组（TS组）。采用Wilcoxon秩和检验和卡方检验分析清扫淋巴结数量及甲状旁腺损伤发生率。

结果

男性16例，女性35例，男女比例为1∶2.19。年龄范围为14～29（25±3.9）岁。两组患者年龄、性别、T分期、TNM分期及手术方式比较，差异均无统计学意义（P＞0.05）。CNP组清扫淋巴结总数高于TS组（Z = -2.258，P＜0.05）。然而，两组之间转移淋巴结总数差异无统计学意义（Z = -0.396，P＞0.05）。在Ⅵ区，CNP组检出淋巴结数高于TS组（Z = -2.461，P＜0.05），但转移淋巴结检出数差异无统计学意义（Z = -1.396，P＞0.05）。CNP组甲状旁腺损伤率为5.5%，TS组为18.2%，差异无统计学意义（χ(2) = 1.568，P＞0.05）。