Sabzghabaee Ali Mohammad, Kelishadi Roya, Golshiri Keivan, Ghannadi Alireza, Badri Shirinsadat
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Med Arch. 2014 Oct;68(5):308-12. doi: 10.5455/medarh.2014.68.308-312. Epub 2014 Oct 15.
Children and adolescents are considered as the best target groups for preventing and controlling the cardiovascular diseases risk factors and reducing mortality in adulthood. Alternative medicine and herbal drugs have been taken into account for managing dyslipidemia in this population. The beneficial effects of Sumac (Rhus coriaria L.) on lipid profile have been confirmed in some laboratory and animal studies. This study was designed to investigate the clinical effects of sumac fruits on dyslipidemia in 12-18 years-old adolescents.
This randomized triple-blinded clinical trial was conducted on 72 obese adolescents with dyslipidemia from August 2011 to June 2012 in Isfahan Cardiovascular Research Center, Isfahan, Iran. Eligible adolescents were randomly assigned to two case and control groups. The control group received placebo capsules and the case group received capsules containing 500 mg of powdered sumac fruits, each three times a day for one month. Biochemical parameters including 12-hrs fasting serum levels of total cholesterol (Total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured before the initiation and after the completion of the study protocol. Statistical analysis was performed using the SPSS software, version 16.0, using Independent Samples T-test, or Paired Samples T-test, for between-group and within-group analysis, respectively.
The plasma levels of Total-C, LDL-C, and TG changed significantly over-time in the case group. Furthermore, between-group analysis showed a statistically significant difference between case and control groups with this regard (P < 0.05, for all statistical comparisons). However, HDL-C levels have not been changed significantly over-time within the case or control group, neither between the two study groups.
In this study, the considerable effects of Rhus coriaria (sumac) on reducing serum levels of Total-C, LDL-C, and TG have been noticed during one-month trial. However, probably due to the concise period of sumac consumption, its effect on HDL-C was not statistically significant.
儿童和青少年被视为预防和控制心血管疾病危险因素以及降低成年期死亡率的最佳目标群体。替代医学和草药已被考虑用于管理该人群的血脂异常。在一些实验室和动物研究中，漆树（Rhus coriaria L.）对血脂谱的有益作用已得到证实。本研究旨在调查漆树果实对12至18岁青少年血脂异常的临床效果。
2011年8月至2012年6月，在伊朗伊斯法罕心血管研究中心对72名患有血脂异常的肥胖青少年进行了这项随机三盲临床试验。符合条件的青少年被随机分为两个病例组和对照组。对照组接受安慰剂胶囊，病例组接受含有500毫克漆树果实粉末的胶囊，每天三次，持续一个月。在研究方案开始前和完成后，测量生化参数，包括12小时空腹血清总胆固醇（Total-C）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平。使用SPSS软件16.0版进行统计分析，分别使用独立样本t检验或配对样本t检验进行组间和组内分析。
病例组中Total-C、LDL-C和TG的血浆水平随时间有显著变化。此外，组间分析显示病例组和对照组在这方面有统计学显著差异（所有统计比较P<0.05）。然而，病例组或对照组内HDL-C水平随时间未显著变化，两个研究组之间也未显著变化。
在本研究中，在为期一个月的试验期间，注意到漆树（Rhus coriaria，漆树）对降低Total-C、LDL-C和TG血清水平有显著效果。然而，可能由于漆树食用时间较短，其对HDL-C的影响在统计学上不显著。
